Role of Imaging in the Management of Intracranial Lesions in Hiv Seropositive Patients
Journal Title: IJAR-Indian Journal of Applied Research - Year 2016, Vol 6, Issue 10
Abstract
Human immunodeficiency virus (HIV) is neurotropic1 and crosses the blood– brain barrier at an early stage in the disease2.Neurological disorders3 cause considerable morbidity and mortality in patients with AIDS with approximately 2/3rd of patients developing CNS involvement during the course of the disease.The spectrum7 of CNS disease in acquired immune deficiency syndrome (AIDS) is wide and can be broadly categorized into 1) Primary effects of HIV 2) Opportunistic infections 3 ) Neoplasms and 4) Vascular disease.Clinical findings are non-specific7, and are often unhelpful in distinguishing between the vast array of neurological disease processes in AIDS..Although recent advances in polymerase chain reaction (PCR) CSF analysis have increased the ability to make a specific diagnosis, a large part of the diagnostic process still relies on radiological interpretation with cerebrospinal fluid analysis. MRI7 is the modality of choice owing to its higher sensitivity of lesion detection and superior contrast resolution compared with CT. Nevertheless, the ready availability of CT allows it to remain a first line investigation, typically in the form of a screening tool prior to lumbar puncture.
Authors and Affiliations
Dr J. Suneeth Charlton, Dr. V. Shanthi Sree, Dr. Vijay Pavan kumar, Dr. Lalith
Keywords
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