Role of Lactoferrinin Fibroblast Growth Factor 2 and Vascular Endothelial Growth Factor in Gingival Wounds
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2019, Vol 8, Issue 3
Abstract
Background: Lactoferrin possesses the ability to promote migration and proliferation of fibroblasts which represents one potential reason for the use of lactoferrin to accelerate the healing process in gingival wounds. Aim and Objectives:To analyze the role of lactoferrin in Fibroblast Growth Factor 2 (FGF-2) and Vascular Endothelial Growth Factor (VEGF) expression in the healing process of gingival wounds. Material and Methods: Twenty eight male Wistar rats were divided into four treatment groups. All rats were incised using a full thickness method on the gingival anterior region of the mandible to which a single application of lactoferrin concentration 10 μg/ml, 20 μg/ml, 40 μg/ml and phosphate buffer saline (control) was made. On the third day post-application, the rats were sacrificed to enable removal of the gingival tissue on the mandible. The role of lactoferrin was evaluated based on FGF-2 and VEGF expression identified through immunohistochemical staining. Results: In general, the group administered with lactoferrin showed higher FGF-2 and VEGF expression compared to that of the control group (p=0.000). The group treated with 40 μg/ml lactoferrin concentration showed a higher FGF-2 and VEGF expression than the groups treated with 10 μg/ml and 20 μg/ml (p=0.000) lactoferrin concentration. Conclusion: Lactoferrin concentration of 40 μg/ml can accelerate the healing process of gingival wounds by increasing FGF-2 and VEGF expression.
Authors and Affiliations
Istiati . , Intan Nirwana, Indra Surjono, Meircurius Dwi Condro Surboyo
Keywords
Related Articles
- EP ID EP630016
- DOI -
- Views 105
- Downloads 0
Tuberculous Dactylitis in a 20 Year Old – A Rare Case Report
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis and manifested by formation of tubercles and caseous necrosis in tissues. Tuberculous spondylitis is the most typical form of disease in the musc...
Role of Melatonin in Down-regulation of Receptor Activator of Nuclear Factor kappa-B Ligand : Osteoprotegerin Ratio in Rat - Bone-Marrow Mesenchymal Stem Cells
Background: Recent studies have reported that melatonin inhibits bone resorption through the regulation of Receptor Activator of Nuclear Factor Kappa-B Ligand (RANΚL): Osteoprotegerin (OPG) ratio in osteoblast. However,...
Birth Defects in India: Magnitude, Public Health Impact and Prevention
Birth defects refer to a group of diverse congenital conditions, which are responsible for stillbirths, neonatal deaths, chronic medical conditions and disability. Due to their low prevalence and high mortality, birth...
Detection of Polyomaviral Large T Antigen in Benign Prostatic Hyperplasia and Prostate Carcinoma Tissues
Background: The role of infectious agents in prostate cancer development has been considered for many years. Polyomaviruses are suspected to be related to human malignancies and they have been frequently detected fro...
Efficacy of Honey Dressing Versus Mechanical Debridement in Healing of Ulcers with Biofilms A Comparative Study
Background: Chronic and delayed healing wounds are the significant health problems globally. Microbial bio burden in the form of biofilms contribute significantly for chronicity and delayed healing. Management of biofilm...