ROLE OF OMEGA-3 FATTY ACID IN HEPATOPROTECTION AGAINST CARBON TETRA CHLORIDE INDUCED LIVER INJURY IN ALBINO RABBITS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 6
Abstract
In the present study hepatoprotective activity of Omega-3-fatty acid against carbon tetrachloride (CCl4) induced hepatic damage in albino rabbits was evaluated. Hepatic injury was induced by administering 0.05ml/Kg body wt. intraperitoneally of CCl4. Omega-3-fatty acid at dose levels of 600 mg/Kg/day were administered to albino rabbits that showed protection from hepatic injury. Omega 3-fatty acid reduced the elevated serum liver enzymes like Aspartate Transferase (SGOT), Alanine Transferase (SGPT), Alkaline Phosphatase (ALP) and serum bilirubin. The result obtained were compared with silymarin (100 mg/Kg body wt. p.o), the standard drug. In conclusion omega-3-Fatty acid (600 mg/Kg/day) were found to hvae very highly significant (p<0.001) hepatoprotective activity comparable to silymarin.
Authors and Affiliations
Renu Khanchandani*| Department of pharmacology, Assistant professor, Govt. Medical College Haldwani, Kumaun University, Nainital, India, Sheo Pratap Singh| Department of pharmacology, Professor, G.S.V.M. Medical College Kanpur, C.S.J.M. University Kanpur, India, Asha Agarwal| Department of pathology, Professor, G.S.V.M. Medical College Kanpur, C.S.J.M. University Kanpur, India
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