Role of Oxidative Stress and Associated Alteration in Enzyme Activities in Obesity Comorbidities
Journal Title: Obesity Research - Open Journal - Year 2017, Vol 4, Issue 2
Abstract
Obesity is defined as having a body mass index (BMI) of 30 kg/m2 or above, with progressively increasing prevalence all over the world in recent years. Obesity is characterized by deposition of abnormally increased body fat, resulting from increased energy intake relative to energy expenditure. The condition is associated with several comorbidities that upsurge risk of morbidity. The purpose of this review is to describe the role of oxidative stress in release of pro-inflammatory mediators that influence fat and glucose metabolism and is associated with altered enzyme activity, which results in insulin resistance and other associated comorbidities. The main pathology is through intensified generation of reactive oxygen species (ROS) and diminution of antioxidant defense, creating a chronic inflammatory situation that is critically important in development of comorbidities. New strategies to combat resultant comorbidities concentrate on weight reduction either solely or coupled with moderately regular exercise. This policy may be sufficient to improve insulin sensitivity, regulate fatty acid metabolism together with refining antioxidant defense of the body. Other approaches encourage modulation of dietary pattern through dietary supplements as vitamins, with or without pharmaceutical antioxidants, which may provide a potential therapeutics approach in obesity comorbidities
Authors and Affiliations
Hala Mourad Demerdash
Keywords
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- EP ID EP553797
- DOI 10.17140/OROJ-4-131
- Views 163
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