Role of Presynaptic receptors in health and disease
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 3
Abstract
Maintenance of homeostasis is the norm of nature. In order to maintain homeostasis in neuronal transmission, fine tuning of neurotransmitter release from the presynaptic nerve terminals is required. This role is played by the receptors present on the presynaptic nerve terminals, which sense the amount of neurotransmitter in the synaptic cleft and in turn regulate the neurotransmitter release. These receptors on activation, operate negative or positive feedback loops to inhibit or stimulate the neurotransmission respectively. Presynaptic receptors are present ubiquitously in all neuronal systems and mediate various physiological roles. They are also being used as pharmacological targets for certain diseases. They are utilized as potential targets for therapeutic agents in schizophrenia, narcolepsy, depression, Parkinson’s disease and Alzheimer’s disease. With advancing technologies for research, new presynaptic receptors are being discovered, their physiological roles demystified and are being manipulated as drug targets. This review focuses on various types of presynaptic receptors present in the different neuronal systems, their physiological role and how they are being employed as pharmacological targets.
Authors and Affiliations
Anandabaskar Nishanthi, Mourouguessine Vimal
Keywords
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