Role of Prophylactic Oral Acyclovir in Recurrent Herpes Simplex Eye Disease
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Purpose: To study the role of long-term treatment with oral acyclovir to prevent recurrences of ocular HSV disease. Material & methods: A retrospective study was carried out in the Department of Ophthalmology at Government Medical College, Patiala, Punjab, India. A total of 50 immunocompetent patients who had had ocular HSV disease within the preceding year in the age group 25 to 45 years were selected to receive 400 mg of acyclovir orally twice daily over a period of 12 months. The history of each patient was taken including a record of age, sex, place of residence, change of place of residence, age at onset of the disease, best-corrected visual acuity was assessed and each patient was thoroughly examined with a slit lamp. Follow-up was done at 1, 3, 9 and 12 months during the treatment period and 6 weekly in the post-treatment observation period. The study outcomes were the rates of development of ocular HSV disease during a 12-month treatment period and a 6-month observation period. Results: The recurrence during the treatment period was 11 cases, (22 %) and the observation period was 8 cases (16 %). During 12 month treatment period, 1 case (2%) had blepharitis or conjunctivitis, 5 cases (10 %) had epithelial keratitis, 4 cases (8 %) had stromal keratitis and 1 case (2%) had iritis. During 6 month observation period, 2 cases (4%) had blepharitis or conjunctivitis, 3 cases (6 %) had epithelial keratitis, 2 cases (4 %) had stromal keratitis and 1 case (2%) had iritis. Conclusion: After the resolution of ocular HSV disease, 12 months of treatment with acyclovir reduces the rate of recurrent ocular HSV disease. Long-term oral acyclovir prophylaxis is most important for patients with a history of HSV stromal keratitis as it can prevent additional episodes and potential loss of vision.
Authors and Affiliations
Dr. Harvinder Nagpal, Dr. Mandeep Kaur
Keywords
Related Articles
- EP ID EP467059
- DOI 10.9790/0853-1802065760.
- Views 74
- Downloads 0
Maluniting Intertrochanteric Fracture – Whats Your Option? Our Experience Of 12 Cases With High Subtrochanteric Osteotomy
Introduction : Malunion of intertrochanteric fractures is common in developing countries as many people rely on indigenous treatment and splintageforfractures.It is not uncommon to see many patients presenting late after...
Comparative Study of Efficacy of Stoppas Procedure Over Bilateral Lichtensteins Hernioplasty in Bilateral Inguinal Hernias
Surgical repair of inguinal hernias is a common procedure done in adults. However recurrence has been reported to occur in 15% of the cases and postoperative pain and disability are frequent. The strengthening of posteri...
Correlation of Inverse Expression of E-Cadherin andAutocrine Motility Factor Receptor with Increased Dedifferentiation ofPancreatic Adenocarcinoma
Pancreatic adenocarcinoma though relatively rare , have dismal prognosis.With intention to find if simultaneous occurrence of destruction of intercellular adhesion is associated with propagation of carcinomatous cells, w...
Study of role of Panchatikta Basti in Abhishyanda Pradhana Prameha
Aims: To study effect of Pancatikta-Basti in Abhishyanda-Pradhan-Prameha. Settings and Design: Panchatikta-Niruha-Basti(medicated enema) has been administered in a dose of 430 ml for 4 consecutive days and on fifth day S...
Significance of Ovarian Stromal Blood Flow Measurement Between Fertile Women with Normal Ovaries and Primary Infertile Women with Polycystic Ovary Syndrome.
Background: Polycystic ovary syndrome is the commonest endocrine disorder in women of reproductive age as this syndrome affect about 5-10% of premenopausal women. Objective : To determine Doppler flow changes within ovar...