Role of Prophylactic Oral Acyclovir in Recurrent Herpes Simplex Eye Disease

Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2

Abstract

Purpose: To study the role of long-term treatment with oral acyclovir to prevent recurrences of ocular HSV disease. Material & methods: A retrospective study was carried out in the Department of Ophthalmology at Government Medical College, Patiala, Punjab, India. A total of 50 immunocompetent patients who had had ocular HSV disease within the preceding year in the age group 25 to 45 years were selected to receive 400 mg of acyclovir orally twice daily over a period of 12 months. The history of each patient was taken including a record of age, sex, place of residence, change of place of residence, age at onset of the disease, best-corrected visual acuity was assessed and each patient was thoroughly examined with a slit lamp. Follow-up was done at 1, 3, 9 and 12 months during the treatment period and 6 weekly in the post-treatment observation period. The study outcomes were the rates of development of ocular HSV disease during a 12-month treatment period and a 6-month observation period. Results: The recurrence during the treatment period was 11 cases, (22 %) and the observation period was 8 cases (16 %). During 12 month treatment period, 1 case (2%) had blepharitis or conjunctivitis, 5 cases (10 %) had epithelial keratitis, 4 cases (8 %) had stromal keratitis and 1 case (2%) had iritis. During 6 month observation period, 2 cases (4%) had blepharitis or conjunctivitis, 3 cases (6 %) had epithelial keratitis, 2 cases (4 %) had stromal keratitis and 1 case (2%) had iritis. Conclusion: After the resolution of ocular HSV disease, 12 months of treatment with acyclovir reduces the rate of recurrent ocular HSV disease. Long-term oral acyclovir prophylaxis is most important for patients with a history of HSV stromal keratitis as it can prevent additional episodes and potential loss of vision.

Authors and Affiliations

Dr. Harvinder Nagpal, Dr. Mandeep Kaur

Keywords

Related Articles

Study of Pattern of Thyroid Dysfunction in Patients with Type 2 Diabetes Mellitus in a Rural Hospital in Karnataka

Background and Objectives: Thyroid dysfunction is known to occur in patients with Type 1 DM, It is due to autoimmunity. The prevalence of thyroid dysfunction in patients with Type 2 DM varies between 10% - 31%. Subclinic...

Smoking Related Knowledge, Attitude And Prevalence Among Medical Students In Princess Noura University

Smoking has been increasing in Saudi Arabia particularly among college and university students specially female students. Yet there is no enough information related to smoking leading factors and reasons behind adopting...

Surgical Management of Proximal Humerus Fractures – Assessment of Results

Background: Proximal humeral fracture whether caused by trauma or related to osteoporosis, requires carefully planned individual treatment. The choice of technique and devices depends on quality of bone, soft tissue, age...

A Study of Advanced Hospital Managaement System

Health care in India as in many other countries is confronted with growing demand for medical treatment and services. The medical records must appropriately have all of the patients’ medical history. Physicians must main...

Etiological Profile of Children (6month – 5 Years) Admitted With Seizures in A Tertiary Care Hospital Of Jharkhand

Background: Seizure is one of the common causes of childhood hospitalization with significant mortality and morbidity. There is limited data regarding acute seizures episodes form the developing countries. Objective: Cur...

Download PDF file
  • EP ID EP467059
  • DOI 10.9790/0853-1802065760.
  • Views 73
  • Downloads 0

How To Cite

Dr. Harvinder Nagpal, Dr. Mandeep Kaur (2019). Role of Prophylactic Oral Acyclovir in Recurrent Herpes Simplex Eye Disease. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS), 18(2), 57-60. https://www.europub.co.uk/articles/-A-467059