Role of Rabeprazole on Chest Discomfort of Uncertain Origin
Journal Title: People's Journal of Scientific Research. - Year 2013, Vol 6, Issue 2
Abstract
Chest discomfort is a common challenge to clinicians; conditions vary from benign to life threatening. The differential diagnosis includes and overlaps cardiovascular, respiratory, gastrointestinal, usculoskeletal & psychiatric problems, all requiring careful history and thorough investigations. However, a significant number of cases remain undiagnosed despite meticulous investigations and thus require empirical therapy (Fagring et al, 2005; Thomas, 2012). The present study was aimed to find the effect of one of the Proton-pump inhibitors (PPIs; Rabeprazole) on patients having non-traumatic, non severe chest iscomfort, diagnosis of which could not be confirmed. Forty eight eligible patients were divided into 2 groups: PPI group and placebo group. Before and after 4 weeks of therapy, they were studied with visual analog scale for pain and its frequency, duration and intensity. Rabeprazole treated patients responded much better than the placebo group. Seventy five percent were pain free or had appreciable relief in pain intensity after 4 weeks. In contrast to Rabeprazole group, in placebo group none became pain free; 45 % had marginal relief while 55 % derived no benefit. Proton-pump inhibitors are of value in the treatment of non specific chest discomfort.
Authors and Affiliations
P. K. Agarwal, , B. Kumar, , Arti, , P. Pankaj,
Keywords
Related Articles
- EP ID EP115047
- DOI -
- Views 97
- Downloads 0
Extragonadal Retroperitoneal Pure Yolk Sac Tumour
We report an extremely rare case of extragonadal retroperitoneal yolk sac tumour in an 8 month old male baby presented with gradual abdominal distension and failure to thrive since 5 months. Ultrasound revealed a well de...
CAN and its Risk Factors for Type2 DM
Diabetic Neuropathy (DN) is a heterogeneous disorder that encompasses a wide range of abnormalities affecting both proximal and distal peripheral sensory and motor nerves as well as the autonomic nervous system. DN is am...
Thoraco-Abdominal Ectopia Cordis: A Rare Entity. Case Report and Review of Literature.
Ectopia cordis is a rare congenital abnormality characterised by partial or complete displacement of the heart outside the thoracic cavity. It can be associated with other congenital abnormalities. The present cas...
Fetal cholelithiasis: A Benign Rarity
A 28 years female, G3P2A0L2, presented to a routine antenatal checkup in OPD with the growth scan at 32 weeks gestation showing incidental findings of multiple echogenic structures in fetal gall bladder with normal hepat...
Beliefs and Practices Among Mothers Regarding Immunization - A Hospital Based Study
During this cross sectional study, 200 mothers who had a live baby of less than one year were interviewed in Pediatric OPD of a tertiary care hospital with the help of pre-validated, semi-structured questionnaire regardi...