Role of Viruses in Periodontal Diseases - A Research Study
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 7
Abstract
Background: Periodontitis is an inflammatory disease affecting supporting tissues of the teeth. However, questions in understanding of this disease remain unanswered as to what initiates change of gingivitis to periodontitis, biologic basis for disease remission, and relapse and what causes site specificity. Viruses are well known to cause disease in oral cavity, but its role as a causative agent in periodontal diseases remains unclear. A deep understanding regarding the etiopathogenesis of these diseases is important for the development of suitable preventive and therapeutic measures. The diverse opinion about the role of viruses in etiology of periodontal diseases has led to various clinical studies. The review focuses on the studies of viral cause for periodontal diseases marking a turning point in periodontal research, which until recently was centered almost exclusively on bacterial etiology. Aim: The aim of this study was to compare levels of herpes viruses in gingival crevicular fluid (GCF) of periodontitis and healthy periodontium subjects. Materials and Methods: A total of 30 patients with periodontitis, 30 patients with gingivitis, and 30 with healthy gingival tissues were selected. GCF samples were analyzed using quantitative real-time polymerase chain reaction to detect and quantify herpes simplex virus (HSV). Levels of HSV were compared between healthy and diseased subjects. Results: The prevalance of HSV 1 was slightly higher in periodontitis subjects in comparison to the control group with a significant correlation ship with clinical parameters of the periodontitis. Conclusion: The prevalance of the HSV viruses in the GCF and its correlation between the clinical parameters of periodontitis may represent an association with the host responses in periodontitis.
Authors and Affiliations
Manik Sharma, Bhanu Kotwal, Nanika Mahajan, Sharad Kharyal, Bhawna Slathia, Vinod Tomar
Keywords
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