RP-HPLC method development and validation for simultaneous estimation of Lopinavir and Ritonavir in tablet dosage form
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 1
Abstract
Simultaneous Estimation of Lopinavir and Ritonavir were carried out by RPHPLC using Acetate buffer (PH 6.5): Acetonitrile (55:45) and column Phenomenex Luna C-18 (250*4.6 mm, 5um) as a stationary phase and peak was observed at 255 nm which was selected as a wavelength for quantitative estimation. After the development of the method, it was validated for specificity, linearity, precision, accuracy, robustness and ruggedness studies.
Authors and Affiliations
Masanam Jyothi Bindu, K. Narendra Kumar Reddy, G Himabindu
Keywords
Related Articles
- EP ID EP33422
- DOI -
- Views 346
- Downloads 0
Preparation and characterization of bioadhesive vaginal gel of Propranolol hydrochloride
The objective of the present investigation was to prepare and characterize a contraceptive vaginoadhesive Propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including Na CMC (1-4% w/w) and tr...
A review on biotransformation
Biotransformation means chemical alteration of chemicals such as nutrients, amino acids, toxins, and drugs in the body. It is also needed to render nonpolar compounds polar so that they are not reabsorbed in renal tubu...
FORMULATION AND IN-VITRO EVALUATION OF LORNOXICAM IMMEDIATE RELEASE AND DICLOFENAC SODIUM SUSTAINED RELEASE BILAYERED TABLETS
The aim of the present work is to prepare bilayered tablet of Lornoxicam and Diclofenac sodium for treatment of rheumatoid arthritis. The bilayered tablet of which Lornoxicam is immediate layer and Diclofenac sodium is...
Diagnosis and management of common clinical presentations of primary glaucomas
The article discusses the common causes of glaucoma, types of glaucoma, diagnosis and treatment. The article also discusses various equipment and their usage in the diagnosis of glaucoma.
Development and validation of HPLC method for simultaneous determination of Ranolazine and Dronedarone in bulk and pharmaceutical dosage forms
A simple, Accurate, precise method was developed for the simultaneous estimation of the Ranolazine and Dronedarone in Tablet dosage form. Chromatogram was run through ODS 3V 250 x 4.6 mm, 5. , 5. Mobile phase contain...