Salivary Total Antioxidant Activity as a Non Invasive Biomarker for Oxidative Stress In Asthmatic Patients
Journal Title: National Journal of Integrated Research in Medicine - Year 2012, Vol 3, Issue 1
Abstract
Background: Bronchial Asthma is a chronic inflammatory disease along with hyperresponsiveness of bronchi. The present study was designed to assess the redox status of patients suffering from bronchial asthma and to compare it with that of normal healthy controls, by determining the total antioxidant activity (AOA) of the serum and saliva and correlating it with the disease status. Method: Total AOA was assayed spectrophotometrically in saliva and serum of two groups; asthmatic patients attending OPD of pulmonary Medicine and healthy controls. The patients were followed for a period of three months after start of therapy and total AOA was measured post therapy. Results: Asthmatic patients exhibited significantly(p<0.05) decreased serum and salivary total AOA as compared to healthy controls. Decreased contents of total AOA in serum and saliva was positively correlated with the severity of disease process. Total AOA in serum was significantly (p<0.0001) higher than salivary AOA in all the categories of asthmatic patients. Total AOA in serum was significantly (p<0.0001) higher than that in saliva of the control subjects. The depressed total AOA returned to near normal values post treatment. In Conclusion: Total AOA in serum and saliva is a good indicator for assessing the severity and progress of bronchial asthma. Salivary total AOA can be taken as a potential biomarker for oxidative stress in asthmatic patients
Authors and Affiliations
K Sayedda, Q S Ahmed
Keywords
Related Articles
- EP ID EP140289
- DOI -
- Views 127
- Downloads 0
Relationship between Smoking and Pulmonary Functions
Background: Smoking is the most important factor contributing to the development of chronic obstructive pulmonary disease and is one of the major health risks in modern times. Aim: The purpose of the present study was...
Prevalence of Microalbuminuria in Newly Diagnosed Type 2 Diabetes Mellitus
Background: Studies in the western literature show a linear relationship between degree of microalbuminuria and body mass index (BMI), blood pressure, and duration of diabetes. Aims and Objectives: This study was aimed t...
A Comparative Study of Serum Lipid Profile between Premenopausal And Postmenopausal Women.
Background & objectives: The effect of the hormonal changes associated with menopause on the serum lipid levels may play an important role in most cardiac related disorders associated with menopause. So the present...
Health Affliction and Social Diligence of Slum Women
Background:Due to rapid urbanization health status of people living in urban slums becomes a topic of priority for public health and urban health planners. Living conditions have a direct impact on public health. One o...
Study of Antibiotic Sensitivity Pattern In Urinary Tract Infection At A Tertiary Hospital
This study was conducted in a tertiary hospital at Bareilly, Uttar Pradesh between Aug 2009 and July 2010 to check the changing pattern of antibiotic sensitivity among uropathogens causing urinary tract infections (UTI...