Search Tools that Improve Portability Anti-Tuberculosis Drugs in Experimental Conditions
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 19, Issue 4
Abstract
The scientific report contains information on the search for drugs that improve the tolerability of anti-TB drugs. The data of experimental substantiation of the combined use of anti-TB drugs and ademetionine as a means of maintenance therapy are presented. The influence of chronobiological rhythms on the toxicity of isoniazid and rifampicin is shown. When studying the effect of sucrose on the toxicity of isoniazid, it was found that its appointment after a meal with the addition of sugar to the diet improves the tolerability of isoniazid. One of the main reasons for the insufficient effectiveness of tuberculosis chemotherapy, along with the increasing drug resistance of the pathogen and low patient compliance, is the high incidence of adverse side effects (NPE) of anti-tuberculosis drugs (PTP). Cancellation of PTP due to the manifestation of severe NPE is made in 20-91 % of patients with tuberculosis. Drug load significantly increases in patients with comorbidities that form a cycle are inevitable problems of pharmacotherapy: a “polymorbidity” → “polypragmasia” → “NPE”. One of the ways to solve the problems associated with the manifestation of severe NPE for the use of PTP in humans is to find means to improve their portability. The purpose of the study: to find means to improve the tolerability of PTP.
Authors and Affiliations
Usov KI
Keywords
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- EP ID EP621791
- DOI 10.26717/BJSTR.2019.19.003320
- Views 163
- Downloads 0
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