Selective Targeting of Cancer Cells using Personalized Nanomedicine
Journal Title: Toxicology and Forensic Medicine – Open Journal - Year 2016, Vol 1, Issue 1
Abstract
Cancer is mostly caused by genetic alteration in either of gain of function and/or loss of function in response to mutagens, ionizing radiations etc. Synthetic lethality raised as an exciting new avenue to kill cancer cells by identifying potential druggable targets. Synthetic lethality define as a lethal interaction between two separate viable mutations when present together within a cell results in cell death, while mutation is only in either of the genes alone, cell remains viable.1 Therefore, synthetic lethality is a new pragmatic strategy for the selective killing of cancer cells by exploring and targeting the synthetic lethal interactors of cancer cell’s specific vulnerabilities like chromosomal instability (CIN) phenotype. Mutation in CIN genes leads chromosomal aberrations (aneuploidy by gene amplification, chromosomal translocation) and deoxyribonucleic acid (DNA) mutations leads to single/double strand break that are repaired by non-homologous end joining (NHEJ) resulting in accumulation of errors, leads to genomic instability, the hallmark of cancer.2
Authors and Affiliations
Rehan Khan
Keywords
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- EP ID EP551486
- DOI 10.17140/TFMOJ-1-e005
- Views 130
- Downloads 0
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