Serum 8-hydroxy deoxyguanine (8-OHdG), DNA damaging Oxidative Stress Biomarker for Type 2 Diabetes Mellitus, the Meta Analysis
Journal Title: Indian Journal of Basic and Applied Medical Research - Year 2018, Vol 7, Issue 2
Abstract
Diabetes Mellitus is one of the diseases with many complications which require a novel biomarker for early diagnosis and treatment. 8-hydroxy deoxyguanine (8-OHdG), DNA damaging oxidative stress biomarker as proven to be a promising biomarker in type 2 diabetes mellitus (T2DM). Method: Data extraction was conducted independently using a standardized data extraction form. Only full length text articles were included in the study. For each included article, we extracted information on the title, authors, publication year, name of the study, sample size, number of diabetes cases and control study, mean (standard deviation) for the 8-HdG level, assay for measuring 8-HdG levels, and statistical methods used for the analysis. Observations and results: Level of serum 8-HdG were highly significantly elevated in patients T2DM compared to healthy control. (Standard mean deference [SMD]) and (95% Confidence Interval [CI] ) +1051.06 (+996.29 to +1135.83). The result of each study also showed that serum 8-HdG in T2DM group was higher than that in healthy control subjects. Our meta-analysis showed that there was highly significant positive association between 8-HdG and DNA damaging oxidative stress risk of T2DM (t-24.3, df-777: p=0.0000000****). Conclusion: 8-HdG used as DNA damaging oxidative stress biomarker of T2DM, helps in early diagnosis, effective therapeutic strategies and monitoring T2DM.
Authors and Affiliations
Santosh E. Bidwe, Prashant Jagannathrao Hisalkar
Keywords
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