Serum C – reactive protein level and other risk factors in age related macular degeneration patients

Journal Title: Indian Journal of Clinical and Experimental Ophthalmology - Year 2017, Vol 3, Issue 4

Abstract

Introduction: Recent evidence suggests that inflammation and abnormalities of innate immunity play a role in the pathogenesis of age-related macular degeneration. In light of the evidence linking inflammation and AMD, it is of interest to determine whether CRP levels and other markers of inflammation are predictive of AMD. Methodology: 50 patients of AMD who satisfy the inclusion and exclusion criteria were included by non-random purposive sampling method. Relevant investigations like FFA and OCT were done. Serum CRP levels were assessed by latex agglutination by SeroCHEK AGAPPE Kit having analytical sensitivity as 6mg/L. Results: Majority of study patients have early AMD changes (70%) as compared to late ARMD changes (30%).Wet AMD corresponds to 16% of all the study patients. Both the groups, early as well as late AMD patients have male preponderance. Majority of patients with early AMD have vision from 6/6 to 6/12 and those with late ARMD have vision 6/60 and less than 6/60. Patients with hypertension, diabetes mellitus, cardiovascular disorders and smokers found no relationship with AMD. In the present study, maximum number of AMD patients have pseudophakia. All the study patients with early as well as late AMD changes, have serum CRP levels below 6mg/L i.e; below the reference value taken in this study. Conclusion: The present study does not support the theory alleging non-specific systemic inflammation in the aetiology and natural history of age related macular degeneration. Though, this may be due the small study sample.

Authors and Affiliations

Nirati Srivastava

Keywords

Related Articles

Correlation of contrast sensitivity with the severity of primary open angle glaucoma

Aims To assess the contrast sensitivity CS in different stages of primary open angle glaucoma and to correlate it with the severity mild moderate severe of glaucomaMaterials and Methods This prospective randomized study...

Duplication of optic canal (a figure of eight anomaly) – case report with review of literature

A duplication of optic canal was discovered on the right side of the skull during routine osteology class of Head and Neck in the Department of Anatomy at Sri Siddhartha Medical College SSMC The main canal was larger and...

Prevalence of glaucoma in patients with obstructive sleep apnea

Introduction: Determining prevalence of glaucoma in patients with obstructive sleep apnea syndrome (OSAS) could be meaningful from public health point of view in Indian scenario, given that only few studies are reported...

Analysis of macular thickness by spectral domain OCT in normal healthy population of Gujrat, India

Introduction Study was conducted to analyse the average macular thickness globally from different age group from the healthy Indian population Study will help to quantify any difference in thickness between gender and ri...

Strabismus surgery complications

Serious complications during or after strabismus surgery are infrequent This article gives a brief idea of the complications either local or systemic that can occur during or after squint surgery Meticulous hemostasis is...

Download PDF file
  • EP ID EP303514
  • DOI 10.18231/2395-1451.2017.0123
  • Views 93
  • Downloads 0

How To Cite

Nirati Srivastava (2017). Serum C – reactive protein level and other risk factors in age related macular degeneration patients. Indian Journal of Clinical and Experimental Ophthalmology, 3(4), 507-512. https://www.europub.co.uk/articles/-A-303514