Serum levels of malondialdehyde and Bilirubin in neonates with different stages of hyperbilirubinaemia
Journal Title: International Journal of Medical and Health Sciences - Year 2015, Vol 4, Issue 4
Abstract
Objectives: Bilirubin, a haemoglobin metabolite acts as an efficient scavenger of reactive oxygen species. Increase of bilirubin production could be a response to an initial oxidative stress. Malondialdehyde (MDA) is a metabolite commonly used as indicator of free radical generation by lipid peroxidation. In this study relationship between the levels of serum bilirubin and malondialdehyde was investigated in neonates with different stages of hyperbilirubinaemia. Materials and Methods: The study included 110 neonates classified into four groups according the total bilirubin (TB) levels: G1 (n=31; TB < 5 mg/dl), G2 (n=31; TB > 5 and <10 mg/dl), G3 (n=31; TB > 10 and <15 mg/dl) and G4 (n=16; TB > 15 mg/dl). Results: The level of malondialdehyde was increased in stepwise manner in the hyperbilirubinaemia groups (G1=4.82 IU/l),(G2=9.21 IU/l), (G3=12.87IU/l), and (G4=17 IU/l).A significant positive correlation was observed between malondialdehyde and bilirubin concentrations in the studied groups G1, G2, and G3 (P<0.001). A significant negative correlation was found between malondialdehyde and haemoglobin (P<0.001) in the same groups. Conclusions: The increases of serum total bilirubin levels in the neonate could be a response to excessive free radical generation and lipid peroxide formation. That may indicate the possible protective effect of antioxidant administration to the mother during pregnancy on the neonate. Serum MDA levels in the neonate could be used as an indicator or predictorof the severity of neonatal jaundice.
Authors and Affiliations
Sameer Hasan Fatani
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