Serum Markers of Epithelial Mesenchymal Transition as Predictors of HCV-induced Liver Fibrosis, Cirrhosis and Hepatocellular Carcinoma.
Journal Title: Electronic Physician - Year 2015, Vol 7, Issue 8
Abstract
Hepatitis C virus (HCV) is a major cause of chronic liver disease in Egypt, leading to hepatic fibrosis, liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Liver fibrosis is characterized by excessive deposition of extracellular matrix (ECM). Newly-recognized pathogenic mechanisms point to the epithelial-mesenchymal transition (EMT) of hepatocytes to matrix synthesizing (myo-) fibroblasts. Transforming growth factor-beta (TGF-β1), bone morphogenic protein (BMP)-7, and connective tissue growth factor (CTGF) are biomarkers reflecting the EMT process. YKL-40 is a glycoprotein member of ECM and plays a role in cancer cell proliferation. The purpose of this study was to determine the serum biomarkers of EMT and its impact on the fibrogenic process and tumorigenesis in HCV-genotype 4 patients.
Authors and Affiliations
Mona M Zoheiry, Shaimaa Aa Hasan, Eman El-Ahwany, Faten M Nagy, Hoda Abu Taleb, Mona Nosseir, Safa Meshaal, Mohamed Darwish El-Talkawy, Inas Raafat
Keywords
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- EP ID EP96090
- DOI 10.19082/1626
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