Serum matrix metalloproteinase-2,9 activity, galectin-3 and systemic inflammation in patients with postinfarction heart failure with preserved ejection fraction
Journal Title: Медичні перспективи - Year 2018, Vol 23, Issue 1
Abstract
The available data suggest that heart failure (HF) after myocardial infarction (MI) is a very frequent event. Recent meta-analysis showed that restrictive mitral filling pattern, the most severe form of diastolic dysfunction, was presented in approximately 10% of the patients with preserved ejection fraction. In addition, restrictive pattern was associated with poor outcome. However, the true prevalence and relevance of diastolic dysfunction after MI remains to be elucidated. Objective: study was designed to evaluate the serum level of MMP-2,9, galactin-3 and C-reactive protein (C-RP) in postinfarction heart failure with preserved ejection fraction (HFpEF) patients. Methods: We divided all included patients into two main groups: 1st group – 20 patients with HFpEF and history of myocardial infarction. 2nd group – 18 patients with HFpEF and stable angina. Standard laboratory blood tests for erythrocyte sedimentation rate (ESR), C-RP, haematological parameters, lipid profile, glucose, renal and liver function tests were performed and calculated body mass index (BMI) for all patients. MMP activity assay and galectin-3 serum level was detected for all patients. Results: It was established significant differences between study groups in MMP-2, MMP-9 levels. Particularly, patients with HFpEF with MI in anamnesis had significantly higher MMP-2, MMP-9 levels on 21.8% and 20.7% respectively. The C-RP and leucocytes levels were significantly higher in 1st group pts. Significant differences in MMP-2, MMP-9 were established in 1st group patients in different age groups (p<0.05) (tab. 3). The MMP 2 level was positively correlated with MMP 9 level (R=0.73, p<0.05), the MMP 9 level – with age (R=0.68, p<0.05). There were no significant differences between galectin-3 level in study group. But we estimated significant differences in galectin-3 level between 1st and 2nd subgroups (p<0.05). Conclusion: Serum MMP-2, MMP-9, CRP and galactin-3 were significantly increased in pts with postinfarction heart failure with preserved ejection fraction compare to pts without myocardial infarction in anamnesis.
Authors and Affiliations
O. Kuryata, A. Zabida
Keywords
Related Articles
- EP ID EP298763
- DOI 10.26641/2307-0404.2018.1(part1).127244
- Views 100
- Downloads 0
Pathogenetic substantiation of surgical treatment of recurrent inguinal hernia
Research purpose was to investigate tissue reactions on implantation of polypropylene mesh, processed with collagen, after plastic surgery of experimental defect in rats in preperitoneal prosthesis localization. Research...
Добовий профіль і варіабельність артеріального тиску в пацієнтів з АГ у поєднанні з ХОЗЛ
Суточный профиль и вариабельность артериального давления у пациентов с АГ в сочетании с ХОБЛ. Потабашний В.А., Фесенко В.И., Буртняк Т.З. На сегодняшний день, несмотря на усовершенствованный поход к ведению больных с АГ...
Рецензія на підручник «Основи екології»: підручник для студентів вищих навчальних закладів / [В.Г. Бардов, В.І. Федоренко, Е.М. Білецька та ін.]; за ред. В.Г. Бардова, В.І. Федоренко. – Вінниця: Нова Книга, 2013. – 424 с.
The influence of studies in Cognitive Wellness University for the elderly people on maintaining their cognitive functions
Progressive aging of the population is accompanied by age-related changes in the body, primarily from the central nervous system, which causes a decline in the cognitive health of man and society as a whole. The emergenc...
Estimation of modern range of fungicides and scope of their application in agriculture of Ukraine as component of state social and hygienic monitoring
The analysis of the range of pesticides, including fungicides, authorized for use in Ukraine and the scope of their application during 1999 - 2012 years was carried out. Statistical research methods were used in the anal...