Serum tau protein level in patients with long-term consequences of the mild brain traumatic injury
Journal Title: Український неврологічний журнал - Year 2019, Vol 0, Issue 1
Abstract
Objective — to study the content of tau protein in blood serum of the patients with long‑term consequences of the mild brain traumatic injury. Methods and subjects. We examined 47 patients aged 22 — 53 years with long‑term consequences of the mild brain traumatic injury with the mean age 47.22 ± 8641 years (14 women, 29.78 % and 33 men, 70.22 %). In this study the serum tau protein level was measured by immunofluorescent method using monoclonal primary and secondary mice antibodies (Sigma) with the consequent measurements of the fluorescent glow with immunofluorescence microscope «Olympus» BX41 (Japany). Data was compared to healthy controls (n = 30, with mean age 27.5 ± 8.33 years) and neurological controls (patients with partial epilepsy, n = 58 with mean age 38.62 ± 9.43 years). Results. Received data showed us that the clinical course of long‑term consequences of the mild brain traumatic injury in patients after mild brain contusion in their anamnesis (38.29 %) was associated with the elevated tau protein serum level (p < 0.05) 0.97 ± 0.01 ОD, healthy controls demonstrated 0.061 ± 0.02 and neurological controls 0.374 ± 0.27) as a marker of axonal impairment, that is important for clinic, prognosis and outcome in the formation of long‑term consequences of brain trauma and these should be counted in the future patients treatment. Clinical and neurological examinations of the patients with long‑term consequences of the mild brain traumatic injury have revealed the presence of multiple neurological manifestations which could indicate the damage of mesencephalic and brain stem structures. Conclusions. The features of the clinical course and formation of long‑term consequences of the mild brain traumatic injury is accompanied by axonal impairment of brain that is reflected in increased serum tau levels.
Authors and Affiliations
Ye. V. Lekomtseva
Keywords
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- EP ID EP594433
- DOI 10.30978/UNJ2019-1-17
- Views 94
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