SERUM URIC ACID AND HYPERTENSIVE COMPLICATIONS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 9
Abstract
BACKGROUND The objectives of this study were- 1. to determine the relationship between raised serum uric acid levels with various complications related to hypertension, and 2. To determine as to whether raised serum uric acid levels could be an independent risk factor in essential hypertension. MATERIALS AND METHODS This observational study was carried out in RMC Kanpur. The study period was from 2016 to 2018. A total of 400 patients were studied of which 200 were cases (hypertensive patients) and 200 were controls (non-hypertensives). If they were having any other condition known to cause raised serum uric acid levels & secondary hypertension, they were excluded. Hypertensive group was further sub-categorized into two groups stage 1 (H1) and stage 2 (H2) based on stage of hypertension (According to JNC VII classification of hypertension). RESULTS The study showed statistically significant (p = 0.001) elevation of SUA levels in cases (patients having hypertension, when compared to that of controls). Also, a positive correlation was found between the severity of hypertension and the duration of hypertension. CONCLUSION There can be a direct association between raised serum uric acid levels and hypertension. Also, the study showed that the serum uric acid levels were significantly increased in patients with Stage 2 hypertension and those with a longer duration of hypertension in comparison with those with stage 1 hypertension and with those having hypertension less than 5 years respectively. Hence on the basis of study, we conclude that “serum uric acid can be used as a prognostic risk factor in essential hypertension.”
Authors and Affiliations
Archana Archana, Sanjeev Kumar Singh
Keywords
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