Sickle Cell Disease Presenting As Sudden Death: Autopsy Findings of 5 Cases
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2011, Vol 1, Issue 2
Abstract
Vasoocclusive crisis or sickle cell crisis is a common painful complication of sickle cell disease in adolescent & adult. Acute episodes of severe pain (crises) are the primary reason that these patients seek medical care in hospital emergency department. Delay or ignorance to this condition is fatal. It is a retrospective study of 5 cases. These cases were brought dead to casualty at Government Medical College & Hospital, Aurangabad. Of these 5 cases, 3 had history of chest pain. After post-mortem examination, the specimens were sent for histopathological examination. The sections of the specimens were studied. Histological examination shows widespread sickling of red blood cells. .?Aggrevating factors leads to hypoxemia which further leads to sickling of red blood cells causing the vasoocclusive crisis & ultimately death of the patient. Of these 5 cases, 4 were not investigated haematologically & biochemically previously, the diagnosis of sickle cell disease made after post-mortem histological examination. It is concluded that, Vasoocclusive crises due to sickle cell can lead to sudden death in previously undiagnosed sickle cell trait / disease patients.
Authors and Affiliations
R Hanmante, K Dhumure, S Chopde, N Kumbhakarna
Keywords
Related Articles
- EP ID EP103207
- DOI -
- Views 113
- Downloads 0
Effect of Deep Breathing Test on Female Patients of Iron Deficiency Anemia
The present study was conducted to find out whether the deep breathing test and thus the autonomic nervous system are affected in female patients of iron deficiency anemia. Material and Method: In this study the change i...
The Results of Posteromedial Release in Clubfoot below the Age of 3 Years
Specific objectives: Congenital Talipes Equinovarus (Clubfoot) is one of the most common foot anomalies which can be treated by serial casting technique with high rate of success. Surgery is indicated for deformities tha...
Effect of various mulches on the growth and yield of strawberry cv. chandler under sub tropical conditions of Punjab
A field study was conducted in the Department of Horticulture, Khalsa College, Amritsar during 2016-2017 to study the effect of various mulches on performance of strawberry cv. Chandler. The runners of strawberry cv. Ch...
A study of clinical profile of respiratory distress syndrome(RDS) in preterm babies
Objective: Study of clinical profile of Respiratory Distress Syndrome in preterm babies. Design: Prospective observational study. Settings: Neonatal Intensive Care unit at tertiary care hospital. Outcome measures: To stu...
Tuberculous endometritis in a post menopausal woman: A case report
Tuberculosis is one of the most important disease in the history of humanity and remains an extra ordinary burden to human health today. It is the second most common infectious disease of adult mortality. Genital TB is r...