Significance of meningococcal hyperinvasive clonal complexes and their influence on vaccines development
Journal Title: Polish Journal of Microbiology - Year 2015, Vol 64, Issue 4
Abstract
[i]Neisseria meningitidis[/i] is a commensal of human nosopharynx and humans are the only reservoir and host of this bacterium. It is also known as dangerous and devastating pathogen, which may lead to rapidly progressing septicemia or meningitis. These severe infections called invasive meningococcal disease (IMD) are one of the major public-health threat worldwide. IMD may occur sporadically, but also in outbreaks, epidemics, and pandemics. Most of the IMD cases in the world are caused by isolates of genetically related groups, clonal complexes (CC), including these with special epidemiological significance called hyperinvasive clonal complexes. It is still unknown why some of them may persist for decades, whereas other are quickly replaced and disappear. As a consequence, epidemiological situation of IMD is variable worldwide and greatly depends on the emergence and widespread of clones belonging to hyperinvasive clonal complexes. Their occurrence has serious implications for health policy, requiring often mass immunization campaigns. Paradoxically, alarming situations caused by hyperinvasive CCs stimulated development and introduction of new vaccines against meningococci. Despite that unquestionable success, isolates of hyperinvasive clones constitute a permanent public health threat, because they are constantly circulating and able to modify their antigenic profiles to escape host immune response. Therefore, continuous monitoring of meningococcal isolates including thorough molecular typing is indispensable and fundamental for taking appropriate preventive measures.
Authors and Affiliations
Izabela Waśko, Waleria Hryniewicz, Anna Skoczyńska
Keywords
Related Articles
- EP ID EP81167
- DOI -
- Views 94
- Downloads 0
<strong>Biocontrol of Gray Mold Decay in Pear by Bacillus amyloliquefaciens Strain BA3 and its Effect on Postharvest Quality Parameters</strong>
The economic losses caused by postharvest fruits diseases have attracted global attention. Traditional chemical fungicide could not meet the need of humans. In recent years, microbial agent which has begun to take the pl...
Monitoring of Virulence Genes, Drug-Resistance in Cylobacter coli Isolated from Golden Retrievers
The investigation was performed on 75 of Golden Retriever puppies. Faecal sles were collected on the 42 day of the puppies life (control). Probiotic preparation was administered on 43 day of the puppies life and 10 days...
Molecular Characterization of the cry Gene profile of Bacillus thuringiensis Isolated from a Caribbean Region of Colombia
In order to characterize native strains of Bacillus thuringiensis of the Colombian Caribbean with toxic effect against insect vectors, 28 samples of bacteria identified as B. thuringiensis were isolated from different so...
Safety Evaluation of Enterocin Producer Enterococcus sp. Strains Isolated from Traditional Turkish Cheeses
The purpose of this study was to determine the antimicrobial activity and the occurrence of bacteriocin structural genes in Enterococcus spp. isolated from different cheeses and also investigate of their some virulence f...
Activity of Natural Polyether Ionophores: Monensin and Salinomycin against Clinical [i]Staphylococcus epidermidis[/i] Strains
[i]Staphylococcus epidermidis[/i], a coagulase-negative staphylococcus, is the most important pathogen responsible for chronic nosocomial infections. These bacteria produce extracellular slime and form biofilms on v...