Significance of Serum Vitamin D Level in Tuberculosis Patients
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 7
Abstract
Introduction: The role of vitamin D in bone homeostasis is well known but nowadays, its role in various essential body processes including prevention of various infective and chronic illnesses like Tuberculosis (TB), by facilitating adaptive and innate immunity in lungs and peripheral blood, is being a matter of debate. Low levels have been associated with respiratory tract infections like TB. Present study aimed to evaluate the level of vitamin D in tubercular patients. Aim: To determine serum vitamin D level in patients with TB and compare it with controls. To compare serum vitamin D level among different types of TB, including Pulmonary TB (PTB), tubercular lymphadenitis and tubercular pleural effusion. Materials and Methods: The present study was a single centre cross-sectional study done during the study period from September 2013 to September 2016 at a tertiary care centre of Uttar Pradesh, India. Total 216 subjects aged between 21 and 60 years were included randomly out of which 113 patients were cases and 103 were controls. Cases of TB were confirmed by sputum Acid Fast Bacilli (AFB) staining, sputum and pleural fluid cytology, Adenosine Deaminase (ADA) of pleural fluid and Fine Needle Aspiration Cytology (FNAC) of lymph nodes. Controls were healthy subjects. Total serum vitamin D levels were measured by Diasorin competitive Radioimmunoassay (RIA) (Autoimmune Diagnostika, GmbH, Strasburg, Germany). Results: The mean serum vitamin D level for patients with TB was 22.4±8.5 ng/mL. Among controls, it was 30.5±8.6 ng/mL (p<0.001). This analysis showed that mean serum vitamin D levels were significantly lower in TB patients as compared with controls and there is no significant difference of serum vitamin D levels in various groups of TB. Also, there was no effect of confounding factors like age, sex and indoor/outdoor activity. Conclusion: The findings of the present study showed that hypovitaminosis-D was highly prevalent among patients with TB as compared to general population in same geographical area and severity of it is not significantly related to different type of TB.
Authors and Affiliations
Salauddin Khan, Nafees Ahmad khan, Mohammad Shameem, Rakesh Bhargva, Irfan Khan, Nithin Anand
Keywords
Related Articles
- EP ID EP523948
- DOI 10.7860/JCDR/2018/28226.11781
- Views 96
- Downloads 0
Impact of High Levels of Pregnancy Associated Plasma Protein-A on Pregnancy
ABSTRACT Introduction: Routinely performed aneuploidy screen takes into account free beta human chorionic gonadotrophins (β-hCG), Pregnancy Associated Plasma Protein-A (PAPP-A), nuchal translucency, and various maternal...
Impact of a Structured Tuberculosis Awareness Strategy on the Knowledge and Behaviour of the Families in a Slum Area in Chhattisgarh, India
Introduction: Of different methods of disease prevention, health education and awareness programmes can empower people regarding several aspects of disease management and thereby enabling them in accessing the right trea...
Overjet Reduction with the Use of ELIBA Device: A Case Report
ABSTRACT The dental overjet, in subjects with skeletal class II, division I, malocclusion represents one of the difficult problems to resolve for the orthodontist. We describe a case of dental overjet reduction, treated...
Assessment of Multidetector Computed Tomography Signs of Unilateral Vocal Cord Palsy: Do We Really Need to Evaluate Coronal Reformatted Images?
ABSTRACT Introduction: Vocal Cord Palsy (VCP) is a common clinical presentation and must be considered as a sign of underlying disease, rather than simply a diagnosis unto itself. Despite of idiopathic causes in nearly...
Leprosy in an Eight-Year-Old Child – An Exceptional Case with Unusual Oral Manifestation
Leprosy is a contagious and granulomatous disease which is caused by Mycobacterium leprae. The incubation period for leprosy is five to seven years and it can take as long as about 30 years before signs and symptoms of l...