SIMULTANEOUS ESTIMATION OF AMOXICILLIN TRIHYDRATE AND BROMHEXINE HYDROCHLORIDE IN ORAL SOLID DOSAGE FORMS BY SPECTROPHOTOMETRIC METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
Two accurate, precise, rapid and economical methods were developed and validated for the estimation of Amoxicillin Trihydrate and Bromhexine Hydrochloride in Bulk and combined Pharmaceutical Dosage Form. First method is First order Derivative method, wherein wavelengths selected for quantitation were 283 nm, for Amoxicillin Trihydrate and 218.6 nm, for Bromhexine Hydrochloride. Second method is area under curve method wherein two wavelength ranges chosen were 271-274nm and 244-248nm for Amoxicillin trihydrate and Bromhexine hydrochloride respectively. In both of the methods linearity for detector response was observed in the concentration range of 100-300μg/ml for Amoxicillin Trihydrate and 2-10μg/ml for Bromhexine Hydrochloride. The proposed methods were successfully applied for the simultaneous determination of both drugs in capsule dosage form. The results of the analysis have been validated statistically and by recovery studies.
Authors and Affiliations
Madhura Dhoka , Vandana Gawande , Pranav Joshi
Keywords
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