SIMULTANEOUS ESTIMATION OF TELMISARTAN AND AMLODIPINE BY UV SPECTROPHOTOMETRIC METHOD USING MULTI COMPONENT MODE OF ANALYSIS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 5
Abstract
A simple, specific, precise and accurate spectrophotometric method has been developed for the simultaneous estimation of Telmisartan and Amlodipine by multi component mode of analysis. For this, simultaneous equation method is used. The method involved measurement of absorbance at two wavelengths, 296 nm and 363 nm of Telmisartan and Amlodipine respectively. Beer’s law obeyed in concentration range of 2 - 22 μg/ mL and 1- 3 μg/ mL for Telmisartan and Amlodipine respectively and limit of detection and limit of quantification is found to be 0.413,0.3 μg/ mL at 296nm ,0.3786 μg/ mL at 363nm and 1.25,0.91 μg/ mL at 296nm ,1.1475 μg/ mL at 363nm respectively. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific. The result of the assay of Telmisartan in Telma-AM tablet was found to be 95.60±0.447% and in Teldey-AM tablet was found to be 96.55±0.912%.The result of the assay for Amlodipine in Telma-AM was found to be 97.87±0.110% and in Teldey-AM was found to be 9102.16±1.620%.
Authors and Affiliations
Muthu Kottai , Rameshwar Sankala, Shiva Chidalla, Satheesh kumar, R. Manavalan
Keywords
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