SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF IRBESARTAN AND HYDROCHLOROTHIAZIDE IN TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
Two simple, sensitive, rapid, accurate and economic spectrophotometric methods were developed for the estimation of Irbesartan and Hydrochlorothiazide in two-component solid dosage form. First method is based on the simultaneous equation, and second method is based on Q analysis (absorbance ratio method). Irbesartan has absorbance maxima at 250 nm, and Hydrochlorothiazide has absorbance maxima at 270.6 nm in methanol. In first method, the linearity was obtained in the concentration range 2-36 g/ml for Irbesartan and 1-18 g/ml for Hydrochlorothiazide. The concentration of drugs in mixture was determined using simultaneous equations. In the second method, the linearity was obtained in the concentration range of 1-24 g/ml for both drugs. The concentrations of the drugs in mixture were determined by using ratio of absorbances at isoabsorptive point and at the max of one of the drugs. The results of analysis have been validated statistically and by recovery studies.
Authors and Affiliations
Kaushik Patel , Satish Patel , Vinay Darji , Rakshit Sonpal
Keywords
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