Single dose of secnidazole treatment against naturally occuring Giardia duodenalis infection in Sakiz lambs
Journal Title: Revista MVZ Cordoba - Year 2014, Vol 19, Issue 1
Abstract
Objective. The purposes of this study were to determine whether secnidazole administered at a single dose of 10 mg/kg, orally, lessens or eliminates Giardia cyst shedding, and to validate the benefit of secnidazole treatment on clinical signs and faecal consistency in lambs naturally infected with Giardia duodenalis. Materials and methods. To this extent weaned 12 weeks of age lambs were selected and randomly assigned into two groups based on placebo (group C, n=7 untreated control group) or treatment (group S, n=10 lambs treated with a single dose of secnidazole at 10 mg/kg). Results. On days 0 and 10, before and after treatment, respectively, reduction in cyst excretion was determined. The faecal consistency and general health were recorded at each sampling day. Conclusions. During the study there was a high (99.98%) reduction in cyst excretion in the secnidazol treatment group compared to the positive control group on day 10, resulting in a significant (p<0.001) reduction, making secnidazole highly effective treatment option.
Authors and Affiliations
Kerem Ural, Ph. D *| University of Adnan Menderes, Department of Internal Medicine, Faculty of Veterinary Medicine, PK: 17, 09016, Isikli, Aydin, Turkey.Corresponding: uralkerem@gmail.com, Nuran Aysul, Ph. D| Adnan Menderes University, Faculty of Veterinary Medicine, Department of Parasitology, Işıklı Mevki, 09016, Aydın, Turkey., Huseyin Voyvoda, Ph. D| University of Adnan Menderes, Department of Internal Medicine, Faculty of Veterinary Medicine, PK: 17, 09016, Isikli, Aydin, Turkey., Bulent Ulutas, Ph. D| University of Adnan Menderes, Department of Internal Medicine, Faculty of Veterinary Medicine, PK: 17, 09016, Isikli, Aydin, Turkey., Osman S. Aldemir, Ph. D| Adnan Menderes University, Faculty of Veterinary Medicine, Department of Parasitology, Işıklı Mevki, 09016, Aydın, Turkey., Hasan Eren, Ph. D| Adnan Menderes University, Faculty of Veterinary Medicine, Department of Parasitology, Işıklı Mevki, 09016, Aydın, Turkey.
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