Sixteen-year Prognosis of Treatment-naive Patients with Hepatitis C Infection
Journal Title: Viral Hepatitis Journal - Year 2019, Vol 25, Issue 1
Abstract
Objectives: In this study, we aimed to evaluate the clinical course of treatment-naive patients infected with hepatitis C virus (HCV) who were followed up in various centers in Turkey. Materials and Methods: This was a retrospective study performed with the participation of 15 centers. Patients aged 18 years and older with HCV infection were included. Results: A total of 391 treatment-naive patients infected with HCV were included in this study. During the follow-up period, the final values of alanine aminotransferase, aspartate transaminase, and total protein were significantly decreased when compared to the initial values (p<0.001, p<0.001, and p=0.005, respectively). In the study group, 19.2% of the patients underwent liver biopsy and 4.1% underwent transient elastography (FibroScan). An increased histological activity index (HAI) score and fibrosis in the second biopsy were observed in one patient, only increased HAI in two patients and increased fibrosis in one patient, as shown on the FibroScan. In the 16 years of the study period, cirrhosis was radiologically detected in only one patient. Conclusion: Even if rapid progression is not observed, close monitoring of the clinical findings related to liver failure and fibrosis with invasive or non-invasive methods may be useful.
Authors and Affiliations
Zehra Karacaer, Selma Tosun, Ayşe Batirel, Ali Acar, Neslihan Çelik, Mustafa Uğuz, Songül Yavuz, Ercan Yenilmez, Mustafa Doğan, Tuğba Yanık Yalçın, Büşra Ergut Sezer, Nefise Öztoprak, Özlem Aydın, İlknur Esen Yıldız, Uğur Kostakoğlu, Pınar Ergen, Rıza Aytaç Çetinkaya, Gül Durmuş, Ramazan Gözüküçük, Seher Ayten Coşkuner, Cumhur Artuk, Emine Fırat Göktaş, Emre Güven, Muhammed Bekçibaşı
Keywords
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