Sodium Glucose Co-Transporter 2 (SGLT-2) Inhibitors: A Review
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 7
Abstract
Worldwide, the number of individuals with diabetes is projected to rise from 366 million in 2011 to 552 million by end of 2030. Despite therapeutic advances, the incidence and prevalence of diabetes continues to surge exacting a tremendous economic burden on countries. The major problem with diabetes is that just 50% of population is able to achieve target glycaemic control with available medications. Type 2 diabetes nearly doubles the risk of cardiovascular and macro vascular complications. Meeting the treatment goal is elusive for many patients. Sodium glucose co-transporter 2 (SGLT2) inhibitors are new class of antidiabetic drug with insulin-independent mechanism of action. The remarkable advantage of these drugs is to increase urinary glucose excretion without inducing hypoglycaemia and promoting body weight loss. This review focuses on physiology underlying the use of SGLT2 inhibitors, their mechanism of action and clinical pharmacology.
Authors and Affiliations
Alok Dixit
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