SOLID DISPERSION INDUCED CO-CRYSTALLIZATION FOR ENHANCED DISSOLUTION RATE OF NEBIVOLOL HYDROCHLORIDE: DEVELOPMENT OF RAPIDLY DISINTEGRATING TABLETS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 2
Abstract
Nebivolol hydrochloride is an antihypertensive agent which is classified as class II drug. Its oral bioavailability is variable due to its poor dissolution and pre-systemic metabolism. The aim of this work was to enhance the dissolution rate of nebivolol hydrochloride both in saliva pH (pH 6.8) and in gastric conditions (pH 1.2). This was done with the goal of developing fast disintegrating tablets with subsequent rapid dissolution. This was achieved by co-grinding of the drug with citric and/or tartaric acid before loading these mixtures in poloxamer by solid dispersion. The resulting dispersion was adsorbed on the solid surface of aerosil. The prepared systems were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffraction in addition to dissolution testing. Co-grinding and solid dispersion developed new crystalline structure of co-crystals type. The developed co-crystals liberated nebivolol at significantly higher dissolution rate. Optimum formulations were prepared as rapidly disintegrating tablets. The developed tablets underwent rapid disintegration with subsequent rapid dissolution of nebivolol. This was recorded irrespective to the pH of the dissolution medium. The developed tablets are thus suitable for intra-oral administration and can liberate most of the drug in the mouth for absorption through the buccal cavity. The formulations can also maintain rapid dissolution rate even after swallowing.
Authors and Affiliations
Ola A. Elfahl
Keywords
Related Articles
- EP ID EP670318
- DOI -
- Views 122
- Downloads 0
VALIDATION OF ASSAY METHOD FOR THE ESTIMATION OF IMATINIB MESYLATE IN TABLET DOSAGE FORM BY HPLC
A simple, sensitive high performance liquid chromatographic method was validated for the estimation of Imatinib Mesylate in pure and in pharmaceutical dosage forms. A 4.6-mm X 150-cm column that contains packing L1 (C18)...
HEMATOLOGICAL CHANGES IN DRUGS ABUSERS ATTENDING TO ABDELAAL ELIDRESI PSYCHIATRIC HOSPITAL
Background: Complete blood count (CBC) is a blood test used to evaluate your overall health and detect a wide range of disorder including anemia, infection and leukemia, Drugs are chemicals structures it is different typ...
PHYSIOLOGICAL CHANGES IN SEX HORMONES OF OSTEOPOROSIS WOMEN IN BASRA PROVINCE/IRAQ
Osteoporosis is the most common bone disease in humans, it is characterized by low bone mass, deterioration of bone tissue and disruption of bone architecture, compromised bone strength and an increase in the risk of fra...
YOGA DARSHANA AND AYURVEDA-A BIRD’S EYE VIEW
Yoga Darshana and Ayurveda are integral part of each other and harmonize each other. The concepts of Yoga Darshana are selectively integrated in Ayurveda to suit its objectives viz., ‘Swasthya Rakshana‟ (maintaining the...
EVALUATION OF TRACE ELEMENTS IN KSHARA (ACHYRANTHES ASPERA).
Mineral elements have very important functions as they serve as structural components of tissues and also functions in cellular and basal metabolism. The plant Achyranthes aspera. is known for various medicinal propertie...