SOLUBILITY STUDIES OF THE β-CYCLODEXTRINS INCLUSION COMPLEXES: A REVIEW
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
The aim of this work was to develop a system for the buccal delivery of the poorly soluble drug, based on poly (ethyleneoxide) (PEO) as bioadhesive sustained-release platform and hydroxypropyl- β -cyclodextrin (HP β- CD) as modulator of drug release. As first, PEO system loaded with drug/HP_CD binary systems with different dissolution properties were tested for drug and HP β-CD release features and compared to PEO system containing drug. When the drug was incorporated as drug/HP β-CD freeze-dried product, all drug content was released from the tablet in about 10 h, displaying a constant release regimen after a transient. The dissolution enhancement was increased on increasing the CD proportion in all the prepared systems. Both the CD type and the preparation technique played an important role in the performance of the system. Irrespective of the preparation technique, the systems prepared using HP-b-CD and DM-b-CD yielded better performance than the corresponding ones prepared using β -CD. This review is intended to give a general background to the use of cyclodextrin as solubilizers as well as highlight kinetic and thermodynamic tools and parameters useful in the study of drug solubilization by cyclodextrins.
Authors and Affiliations
Shikhar Gupta , G. C. Soni , S. K. Jain , Aviral Katiyar, Sanjay Vishwakarma
Keywords
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