Some dopaminergic genes polymorphisms are not associated with response to antipsychotic drugs in schizophrenic patients.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 3
Abstract
Background: Therapeutic effects of all clinically used antipsychotics are related to the reduction of dopaminergic transmission in the limbic system. The aim of present study was two-fold. First, efficacy of atypical drugs (ziprasidone and olanzapine) against schizophrenia symptoms was compared to that offered by a typical antipsychotic medication, perazine. Second, associations between some dopaminergic genes polymorphisms and therapeutic response to antipsychotics were assessed in the same group of schizophrenia patients. Methods: One hundred ninety one Caucasian patients admitted with exacerbation of paranoid schizophrenia were genotyped for polymorphisms of the DRD2 [the ins/del -141C (rs1799732) and exon 8 (rs 71653615)], DRD2/ANKK1 Taq IA(rs 1800497), DAT1 (the 40 bp VNTR), COMT (rs 4680), and MAOA gene (the 30 bp VNTR in promoter). The patients were randomly assigned to the treatment with perazine, olanzapine or ziprasidone given as monotherapy for 3 months. Treatment efficacy was measured from baseline (T0) to T1 (14 days) and T2 (3 months). A retention rate was also assessed at T1 and T2. Results: The three antipsychotics did not differ in terms of reduction of the PANSS score or retention rate at the follow-up. There was no interaction between the investigated polymorphisms and response to the antipsychotic treatment. Conclusions: The present results suggest that: i) there are no major differences in short-term efficacy or effectiveness of atypical (olanzapine, ziprasidone) and typical (perazine) antipsychotic drugs; ii) the studied polymorphisms are not primarily involved in treatment response to antipsychotics in schizophrenia patients.
Authors and Affiliations
Piotr Tybura, Agnieszka Samochowiec, Aleksander Beszlej, Anna Grzywacz, Monika Mak, Dorota Frydecka, Przemysław Bieńkowski, Paweł Mierzejewski, Andrzej Potemkowski, Jerzy Samochowiec
Keywords
Related Articles
- EP ID EP119775
- DOI -
- Views 125
- Downloads 0
Lymphocyte-suppressing action of angiotensin-converting enzyme inhibitors in coronary artery disease patients with normal blood pressure.
The clinical effectiveness of angiotensin-converting enzyme (ACE) in the prevention and treatment of cardiovascular disorders partially results from its anti-inflammatory action. No previous study has investigated the ef...
Role of nuclear factor kappaB in the central nervous system.
The aim of this review was to assemble current literature data on nuclear factor kappa B (NF-kappaB). Many authors believe that NF-kappaB, a transcription factor, has essential influence on the regulation of numerous gen...
GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR(5).
In the present study, the effects of the γ-hydroxybutyrate (GHB) analog GET73 on hippocampal glutamate transmission have been evaluated by an approach combining in vivo microdialysis with the in vitro evaluation of tissu...
Dexamethasone reduces locomotor stimulation induced by dopamine agonists in mice.
The interaction between glucocorticosteroids and the dopaminergic system has attracted considerable attention in recent years since this link could be involved in certain psychopathological conditions including depressio...
Macrophages and depression - a misalliance or well-arranged marriage?
Depression is a severe medical condition with multiple manifestations and diverse, largely unknown etiologies. The immune system, particularly macrophages, plays an important role in the pathology of the illness. Macroph...