Species identification and antifungal susceptibility of Candida isolated from urine specimens in a tertiary care hospital
Journal Title: IP International Journal of Medical Microbiology and Tropical Diseases - Year 2018, Vol 4, Issue 2
Abstract
Introduction and Objectives Urinary tract infections caused by Candida have become frequent as a result of increased use of broad spectrum antibiotics corticosteroids immunosuppressive agents bladder catheters and increasing cases of diabetes mellitus The morbidity and mortality caused by nonalbicans Candida NAC species are increasing A prospective study was done to study the incidence of nonalbicans Candida in patients with urinary tract infectionMaterials and Methods The speciation of Candida isolated from urine samples of patients was done using conventional yeast identification protocols and chrome agar Antifungal susceptibility testing was done by the disc diffusion method to amphotericin B nystatin and azolesResults Candiduria was diagnosed in 13 of patients with urinary tract infection Six species of Candida were isolated which include Calbicans 368 C tropicalis 229 C krusei 136 C parapsilosis 136 C guilliermondii 52 and C kefyr 79 All Candida albicans isolates were sensitive to Amphotericin B and nystatin Ketoconazole was the next effective drug 75 followed by clotrimazole 7142 fluconazole 706 and itraconazole 625 Amongst the nonalbicans Candida species Nystatin was the most sensitive drug 89 followed by Amphotericin B 64 fluconazole 622 itraconazole 588 clotrimazole 588 and ketoconazole 47Conclusion Urine samples yielded more of nonalbicans Candida Among the nonalbicans Candida Candida tropicalis was the predominant isolate Antifungal resistance was more in nonalbicans Candida than in Candida albicans Hence there is need for speciation and susceptibility testing of Candida species to optimize the selection of antifungal agents to provide the best possible patient careKeyword Candiduria antifungal susceptibility testing Candida speciation Chrome agar urinary tract infection Non albicans Candida
Authors and Affiliations
Anju Sebastian, Archana S
Keywords
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- EP ID EP485845
- DOI 10.18231/2581-4761.2018.0016
- Views 95
- Downloads 0
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