Specific prophylaxis of rabies in domestic and livestock animals
Journal Title: Бюлетень "Ветеринарна біотехнологія" - Year 2017, Vol 30, Issue
Abstract
Introduction. An effective strategy for preventing rabies is controlling rabies in the host reservoir with vaccination. Rabies vaccine has proven to be the most effective measure for coping with this fatal viral zoonotic disease of warm-blooded animals, including human. The goal of the work. To study the effectiveness of rabies vaccination in laboratory and field conditions. Materials and methods. In experiments used clinically healthy 10 dogs and 10 cats. Before immunization and on 7, 14, 21, 27 and 41 day blood sera were obtained and tested for the level of rabies antibodies by FAVN. Also 13 cattle were used, which have not been vaccinated against rabies earlier. In experiment we used two groups of cattle. Clinically healthy animals were in the first group. The second group consisted of 8 animals, which serum blood contained antibodies against different serogroups of Leptospira. For comparison tensions of rabies immunity in healthy animals and animals with positive reaction for leptospirosis, blood samples were taken on the 106th, 180th, 274th and 366th day after rabies vaccination. Blood serum was obtained and investigated for the presence of specific antibodies. Results of research and discussion. As a result of studies of immunized dogs blood serum, it was found protective level of rabies antibodies on the 7th day of study, the mean value was 1.01±0.29 IU/ml. Dynamics of antibody formation characterized by increasing till 27 days, when it gained it’s maximum - 23.9±3.51 IU/ml. Results of the study of blood serum obtained from the cats show that blood serum antibody titer reached the minimum protective level (1.27±0.15 IU/ml) on the 7th day of research. The blood serum antibody in cats increased until 27 days, when it gained its maximum (28.36 ± 1.69 IU/ml). Result of studies of immunized cattle revealed that in clinically healthy animals through all period of researches protective antibody titer ranged within 1.55±0.2 - 0.61±0.08 IU/ml. Unlike the group of healthy animals, sera tests of cattle, which were serologically positive for leptospirosis, showed a completely different situation. Results of analysis on the 274th day showed that 3 of 7 animals had antibody titer below the minimum level. The critical situation was on the 366th day after immunization, when mean level of antibody titer was 0.35±0.13 IU/ml. Conclusions and prospects for further research. In our opinion, formation of anti-rabies post-vaccination immunity in cats and dogs finishes on 27th days. Obtained results indicate the necessity of revaccination of cattle in second group on 180th day after the first immunization.
Authors and Affiliations
Alina Nikitova, Ivan Polupan, Anastasia Lynok, Alexander Martyniuk, Vitalii Nedosekov
Keywords
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- EP ID EP272277
- DOI 10.31073/vet_biotech30-23
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