Spectrophotometric Analysis for the Quantification of Rivaroxaban in Bulk and Tablet Dosage Form
Journal Title: International Journal of Medicine and Pharmaceutical Sciences (IJMPS) - Year 2017, Vol 7, Issue 5
Abstract
Objective This study reveals the report on the development of two spectrophotometric methods (A and B), for the determination of rivaroxaban in bulk and Xeralto tablets. Methods Method A involves the formation of colored tris (1, 10-phenanthroline)-iron (II) complex, upon reaction of rivaroxaban with iron (III)-1, 10-phenanthroline mixture in acidic media. The colored complex is spectrophotometrically measured at 525 nm. Method B involves the interaction of RXN with acetaldehyde with chloranil, to give colored vinylamino substituted quinones. The colored product exhibit absorption maxima at 655 nm. Effects of experimental variables on the determination of rivaroxaban have been examined and optimized. The proposed methods are validated by following ICH guidelines. Results Beer's law correlating the absorbance with rivaroxaban concentration was obeyed in the range of 5-62.5 μg/ml and 10-100 μg/ml, for methods A and B, respectively. Limits of detection and quantitation values were 0. 101μg/ml and 0.306μg/ml, respectively, for method A, and their respective values for method B were 0.116μg/ml and 0.351 μg/ml. The values of accuracy, precision, selectivity, robustness and ruggedness are within the adequate limit. The proposed method was applied successfully, for the quantification of rivaroxaban in Xeralto tablets, with good accuracy and precision. Conclusion The proposed methods A and B are valuable, in terms of its regular application in quality control assay of rivaroxaban.
Authors and Affiliations
Burla Sunitha Venkata Seshamamba, Chandra Bala Sekaran
Keywords
Related Articles
- EP ID EP245194
- DOI -
- Views 112
- Downloads 0
Prevalence and Health Seeking Behavior among Specific Women Group on Reproductive 3 Tract Infection in Rural Community Area of Kancheepuram District, Tamil Nadu: A Cross Sectional Study Report
A community based cross sectional study was conducted to assess the Prevalence and Health Seeking Behavior on Reproductive Tract Infection among reproductive age group women, in a selected rural community area of Tamil N...
THE EFFECTIVENESS OF TIGECYCLINE IN MULTIDRUG RESISTANT INFECTIONS IN INTENSIVE CARE UNIT
Background Infection with multidrug resistant (MDR) organism represent an important cause of a poor patient outcome, prolonged hospitalization and mortality. Patients in the intensive care unit at increased risk of devel...
“COMPARATIVE CLINICAL TRIAL BETWEEN BRONCHOSCOPIC AND NON- BRONCHOSCOPIC BRONCHOALVEOLAR LAVAGE IN DIAGNOSIS OF VENTILATOR ASSOCIATED PNEUMONIA”
Background Our objective was to compare the results of bronchoscopic BAL and non-bronchoscopic BAL on diagnosis of ventilator-associated pneumonia (VAP). Patients and Methods The prospective comparative clinical trial wa...
PRE- EXPERIMENTAL STUDY TO ASSESS THE EFFECTIVENESS OF STRUCTURED TEACHING PROGRAMME ON KNOWLEDGE REGARDING THERAPEUTIC COMMUNICATION AMONG STAFF NURSES WORKING IN PSYCHIATRIC HOSPITALS CHENNAI
Pre- experimental study to assess the effectiveness of structured teaching program on level of knowledge regarding therapeutic communication among staff nurses working in psychiatric hospitals, Chennai. Objectives were:...
TRAINING THE NURSES - PIVOTAL TO HOSPITAL SERVICE DELIVERY IMPROVEMENT
In current scenario it’s clearly is visible that the way in which Indian hospital are operating is changing. This change can be well associated with the pivotal role of nurses training in the hospital servic...