SPECTROPHOTOMETRIC DETERMINATION OF ROSUVASTATIN IN PURE FORM AND PHARMACEUTICAL FORMULATIONS THROUGH ION-PAIR COMPLEX FORMATION USING BROMOCRESOL GREEN

Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11

Abstract

Objective: A simple, direct and accurate spectrophotometric method has been developed for the determination of rosuvastatin (RSV) in pure and pharmaceutical formulations by complex formation with bromocresol green (BCG).Methods: The method involves the formation of a yellow ion-pair complex between rosuvastatin (RSV) and bromocresol green (BCG) reagent in chloroform.Results: The formed complex was measured at lmax 416 nm against the reagent blank prepared in the same manner. Variables were studied in order to optimize the reaction conditions. Beer’s law was obeyed in the concentration range of 0.482-24.077 μg/ml with good correlation coefficient (R2= 0.9996). The relative standard deviation did not exceed 2.8%. The limit of detection (LOD) and the limit of quantification (LOQ) were 0.045 and 0.13 μg/ml, respectively. No interferences were caused by excipients, aspirin (ASP) and fenofibrate (FEN), but Ezetimibe (EZE), clopidogrel (CP), telmisartan (TEL), glimepiride (GLM) and diltiazem (DIL), interfere.Conclusion: The developed method is applicable for the determination of rosuvastatin in pure and different dosage forms with an average recovery of 96.0 to 105.0% and the results are in good agreement with those obtained by the RP-HPLC reference methods. 

Authors and Affiliations

Abdul Aziz Ramadan, Hasna Mandil, Rafif Alsayed-ali

Keywords

Related Articles

STREPTOMYCES CELLULOSAE VJDS-1, A PROMISING SOURCE FOR POTENTIAL BIOACTIVE COMPOUNDS

Objectives: The aim of the present study was to isolate, identify and analyze the phylogenetic characteristics of the potent actinobacterial strain VJDS-1 with antagonistic activities isolated from Mangrove ecosystems of...

ANTIBIOTIC USE AT PRIMARY HEALTHCARE CENTERS IN SURABAYA: A SURVEILLANCE STUDY

Objective: Antibiotics are considered to be overprescribed in primary health care centers. This study aimed to investigate the defined daily dose (DDD) of antibiotics per 1000 patients visit in a year in primary health c...

THE METAL COMPLEXES OF 1-(PHENYLAMINO)-4, 4, 6-TRIMETHYL-3, 4-DIHYDROPYRIMIDINE-2-(1H)-THIONE: PREPARATION, PHYSICAL, SPECTROSCOPIC STUDIES AND ANTIBACTERIAL PROPERTIES

Objective: The metal complexes of 1-(Phenylamino)-4, 4, 6-trimethyl-3, 4-dihydropyrimidine-2-(1H)-thione: preparation, physical and spectroscopic studies and preliminary antibacterial properties.Methods: Complexes of bid...

ANTIBIOTIC SENSITIVITY PATTERN OF CITROBACTER SPP. ISOLATED FROM PATIENTS WITH URINARY TRACT INFECTIONS IN TERTIARY CARE HOSPITAL IN SOUTH INDIA

Objectives: Urinary tract infection (UTIs) caused by Citrobacter species have been described in 5 to 12% of bacterial urine isolates in adults. The genus Citrobacter is a distinct group of aerobic Gram-negative bacilli f...

MINERAL CONTENT OF SOME EDIBLE MEDICINALLY IMPORTANT LEAFY VEGETABLES OF KAMRUP DISTRICT OF ASSAM, INDIA

Objective: The aim of the present study was to determine the mineral components of Amaranthus spinosus, Oxalis corniculata, Bacopa monnieri, Paedaria foetida and Centella asiatica.Methods: Mineral compositions of the fiv...

Download PDF file
  • EP ID EP578152
  • DOI -
  • Views 85
  • Downloads 0

How To Cite

Abdul Aziz Ramadan, Hasna Mandil, Rafif Alsayed-ali (2015). SPECTROPHOTOMETRIC DETERMINATION OF ROSUVASTATIN IN PURE FORM AND PHARMACEUTICAL FORMULATIONS THROUGH ION-PAIR COMPLEX FORMATION USING BROMOCRESOL GREEN. International Journal of Pharmacy and Pharmaceutical Sciences, 7(11), 191-198. https://www.europub.co.uk/articles/-A-578152