SPECTROPHOTOMETRIC DETERMINATION OF ROSUVASTATIN IN PURE FORM AND PHARMACEUTICAL FORMULATIONS THROUGH ION-PAIR COMPLEX FORMATION USING BROMOCRESOL GREEN
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: A simple, direct and accurate spectrophotometric method has been developed for the determination of rosuvastatin (RSV) in pure and pharmaceutical formulations by complex formation with bromocresol green (BCG).Methods: The method involves the formation of a yellow ion-pair complex between rosuvastatin (RSV) and bromocresol green (BCG) reagent in chloroform.Results: The formed complex was measured at lmax 416 nm against the reagent blank prepared in the same manner. Variables were studied in order to optimize the reaction conditions. Beer’s law was obeyed in the concentration range of 0.482-24.077 μg/ml with good correlation coefficient (R2= 0.9996). The relative standard deviation did not exceed 2.8%. The limit of detection (LOD) and the limit of quantification (LOQ) were 0.045 and 0.13 μg/ml, respectively. No interferences were caused by excipients, aspirin (ASP) and fenofibrate (FEN), but Ezetimibe (EZE), clopidogrel (CP), telmisartan (TEL), glimepiride (GLM) and diltiazem (DIL), interfere.Conclusion: The developed method is applicable for the determination of rosuvastatin in pure and different dosage forms with an average recovery of 96.0 to 105.0% and the results are in good agreement with those obtained by the RP-HPLC reference methods.Â
Authors and Affiliations
Abdul Aziz Ramadan, Hasna Mandil, Rafif Alsayed-ali
Keywords
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