Spectrum of Hemoglobinopathies Diagnosed by High-Performance Liquid Chromatography in Western Odisha
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 8
Abstract
Hemoglobinopathies are the most common genetic disorders reported in the World. The aim of our study was to establish the spectrum of the different haemoglobinopathies presenting in a tertiary medical college in western Odisha to help develop management, prevention and control programmes in the community. Patients who had any form of haemoglobinopathy underwent HPLC analysis, With regard to the different haemoglobin fractions our study revealed that HbSS (sickle cell disease) is the most common abnormal haemoglobin in Western Odisha, followed by HbAS (Sickle cell trait).Both beta thalassemia major and minor were associated with sickle cell haemoglobinopathy, more commonly with sickle cell disease. Castes like kulita, harijan, aghariya and chasa presented with a higher incidence of different haemoglobinopathies. HbE was found to be very uncommon. HbF was found to have a higher level in all haemoglobinopathies
Authors and Affiliations
Dr Chandan Kumar Das
Keywords
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