Spermatogenic Assessment in Mangiferin Induced Male Rats in Comparis0n to Crude Extract of Mangifera Indica (BARK)
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 1
Abstract
Since ancient ages, mango tree is worshiped by the people of different counties like India .It has great economic as well as medical values in different fields of clinical treatment like fever, cough, hepatitis, diarrhoea, etc. But the medicinal value in different on its different parts like leaf, stem, bark etc .The bark has been reported vastly to have pharmacological importance. Through reports are available mostly on crude extract of bark but the report on pure mangiferin is very limited. Specifically few reports on reproduction by crude extract treatments are available but no such authentic report of pure mangiferin on male reproduction is found till date. So, we tried to study of pure mangiferin and crude extract of it as a trial study. The adult male rats were injected (i.p) extract and pure mangiferin at the dose of 0.1ml mother and 1mg/100gm b.wt/day accordingly for 14 days consecutively parallel to vehicle control. The study of sperm motility showed significant reduction in all the treated groups, but is predominant in extract treatment. Again the total sperm count was significantly reduced in extract treated group but was increased significantly in pure drug treated group when compared to control .The abnormal sperm showed significantly rise in treated group but in abnormalities were comparatively lower in pure group in compare to extract group. Sperm viability by Eosin nigrosin stain study also showed the same nature alike the morphology study. The SEM study of Sperm morphology and epididymal also histology supported the above statement i.e. distortion of acrosomal cap in sperm head, abnormal tail and neck, which was also confirmed by Gimsa staining further.
Authors and Affiliations
Nirmal Pradhan
Keywords
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