Sputum Concentration Improves Diagnosis of Pulmonary Tuberculosis Cases in Children at a Tertiary Care Centre
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 1
Abstract
Background: Bacteriological diagnosis of tuberculosis (TB) is largely dependent on Ziehl-Neelsen (ZN) microscopy. This method has a low sensitivity. In this study we performed a prospective evaluation direct and concentrated smear microscopy on three early morning sputum specimens from patients suspected of having tuberculosis. Materials & Methods: A total of 100 patients including HIV patients, of all age groups and sex, presenting to the OPD for the first time, with clinical suspicion of pulmonary or extrapulmonary TB was included in the study. All the demographic details of the patients were noted and consent was taken from patients. Results: A total of 300 sputa were analyzed by direct and concentration methods with culture as a gold standard. In patients under 15 years both methods were different in sensitivity (62.5% vs. 100%, CI= 95%, P<0.05), in patients of 15 years of age and more, both methods had the almost sensitivity (50% vs. 57.14%, CI= 95%, P = 0. 87). Regardless of age groups both methods were different in sensitivity (87.5% vs.77.77%, C.I= 95%, P = 0.001). Conclusion: We concluded that the sensitivity of the concentration technique was markedly increased in pediatric age (< 15 years), this increase has influenced the overall sensitivity in all patients. Considering the low cost and safety of the technique and greater sensitivity, this method can be of vital importance at least for patients under 15 years of age with negative smears on direct technique.
Authors and Affiliations
Krishna Kumar Mani, Ravi Kumar
Keywords
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- EP ID EP530283
- DOI 10.21276/ijmrp.2018.4.1.090
- Views 94
- Downloads 0
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