State of Indicators of Apoptosis and Angiogenesis Processes in Patients with Inactive Pituitary Adenomas
Journal Title: Міжнародний ендокринологічний журнал - Year 2015, Vol 6, Issue 70
Abstract
In the article, the authors analyze data from 71 patients with inactive pituitary adenomas (IPA) aged 18 to 70 years. The absence of correlation between the decline in eNOS enzyme activity and parameters of pro- and antiapoptosis and angiogenesis regulation was found, indicating the independence of these processes in the mechanisms of IPA formation. In patients with IPA and without burdened family history, the index of eNOS and VEGFR-2 correlation increases that indicates an enhancement in the processes of inhibition of angiogenesis and proliferative activity of tissues. The studies did not establish the dependence of violations in patients with microadenomas and macroadenomas, differences by gender, duration of disease, hereditary genetic traits, etc. This underlines the need for further researches in this direction.
Authors and Affiliations
D. Sh. Kholova, Z. Yu. Khalimova, Yu. M. Urmanova, D. A. Aliieva, H. O. Alimukhamedova
Keywords
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- EP ID EP219428
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