Stevens - Johnson Syndrome and Intestinal Perforation following regorafenib Administration for Metastatic Rectal Cancer: A Case Report
Journal Title: Clinical Medical Reviews and Case Reports - Year 2016, Vol 3, Issue 2
Abstract
Regorafenib monotherapy is useful for the treatment of colorectal cancer (CRC), which is refractory to multiple anti-cancer agents. However, it is associated with a high incidence of adverse events such as hand-foot skin reactions, elevated liver enzymes, etc. Although there are few reports of Stevens-Johnson syndrome (SJS) or intestinal perforation associated with regorafenib, such events should be taken into consideration, as with various other anti-cancer therapies, including bevacizumab.
Secondary Adrenocortical Insufficiency as a Result of Chronic Fentanyl Treatment: A Case Report
Hypothalamus-Pituitary-Adrenal (HPA) may be disturbed by drugs, including opioids. In fact, opioids are a well-recognized cause of hypogonadotropic hypogonadism due to its effects in the hypothalamic-pituitary-gonads axi...
Acute Disseminated Encephalomyelitis (ADEM) Secondary to Neurosyphilis
Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune demyelinating disease of the central nervous system. For our case presentation, a 52-year-old Hispanic male presented with altered mental status and focal...
Significance of Antiphospholipid Antibodies in Essential Cryoglobulinemia: A Case Report and Review of Literature
Cryoglobulinemia is a rare immune-complex-mediated small vessel vasculitis that has a smoldering clinical course and can potentially involve multiple organ systems. The discovery of its relationship with hepatitis C infe...
Aeroportia - A Rare Finding for a Frequent Disease
A 69-year-old female was admitted to our hospital with complaints of abdominal pain and diarrhea for the last 2 weeks. She was obese, diabetic, and had peripheral arterial disease, but no history of bowel disease or prev...
Mobility Scooter Accidents - Need for Preventative Action?
Mobility scooters are three- or four-wheeled vehicles, powered by an electric engine. Often acquired by the elderly population, they neither require a drivers' license, nor an assessment of operator skills prior to use....