Stimulation of iron-restricted erythropoiesis with iron (III) isomaltoside 1000 does not oversaturate transferrin in haemodialysed patients with anaemia – a retrospective study
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 10
Abstract
Introduction. Iron deficiency, either absolute or relative, contributes to the developmentof anaemia in end-stage renal failure. Intravenous iron supplementation is a standardtreatment in patients on haemodialysis therapy. Available intravenous iron preparationsdiffer in toxicity, dependent on the amount of potentially harmful free iron that is detachedfrom the transporting particle. Interception of free iron by apotransferrin results in TSATincrease.Aim. The aim of this study was to assess the changes in TSAT after injection of iron (III)isomaltoside 1000 in haemodialysis patients.Material and methods. The study was conducted in two groups of anemic patientson maintenance haemodialysis for end-stage renal failure. Each group comprised 8 patientswith baseline TSAT < 35%. Two weekly doses of 100 mg iron (III) isomaltoside1000 were administered in the first group. In the second group, 200 mg iron (III) isomaltoside1000 was administered as the first weekly dose, followed by a 100 mg dose. Thechanges in TSAT were measured 210 minutes after each administration. The results wereanalysed with the STATISTICA software.Results. Both 100 and 200 mg of iron (III) isomaltoside 1000 caused statistically significant,transient increase in TSAT values. TSAT values after 200 mg isomaltoside weresignificantly higher in comparison to 100 mg (p = 0.026264). In neither case the TSATvalues reached 60%. No adverse effects of supplementation were observed.Conclusions. In haemodialysis patients iron (III) isomaltoside 1000 causes moderateand transient increase in TSAT values. The 200 mg iron (III) isomaltoside 1000 seems safeonly in patients with significant iron depletion.
Authors and Affiliations
Katarzyna Chmiel-Majewska, Dorota Daniewska, Tomasz Żelek, Ryszard Gellert
Keywords
Related Articles
- EP ID EP77352
- DOI 10.5604/08606196.1189836
- Views 184
- Downloads 0
Nowe leki i ich działania niepożądane w terapii przewlekłych zapaleń wątroby typu C
Na początku lat 90. interferon rekombinowany stosowany w terapii chorych przewlekle zakażonych HCV był skuteczny u około 15% pacjentów. Skojarzenie tej terapii z rybawiryną, a następnie zastąpienie interferonu rekombinow...
Ekspresja transportera dopaminy w limfocytach krwi obwodowej w chorobie Parkinsona
Wstęp. Limfocyty krwi obwodowej służą jako model do badań zmian układu neuroprzekaźnik-receptor.Cel pracy. Celem pracy było badanie ekspresji transportera dopaminy (DAT) w limfocytach krwi obwodowej pacjentów z chorobą P...
Clinical characteristics and videofluoroscopic swallowing study findings in children with swallowing disorders
Introduction. Swallowing disorders are a relevant but often unrecognized and underestimated problem in children. Sometimes they lead to aspiration pneumonia.Aim. The aim of this study was to show the usefulness of the vi...
Zmiany zwyrodnieniowe kręgosłupa a leczenie i problem społeczny
Omówiono aktualny stan wiedzy o przyczynach powstawania i naturalnym przebiegu zmian zwyrodnieniowych kręgosłupa. Przedstawiono powikłania choroby zwyrodnieniowej kształtujące obraz kliniczny, w którym dominują bóle i ob...
Diagnosis of focal liver lesions – visualizing examinations<br /> or biopsy? Our experience
Introduction: Owing to wide availability of modern visualizing diagnostic methods focal liver lesions are often diagnosed.Material and Methods: The retrospective study was conducted involving the patients with focal live...