Structural characterization of Carane Derivative Stereoisomers
Journal Title: Acta Physica Polonica, A - Year 2002, Vol 101, Issue 5
Abstract
The paper reports on structural investigation and phase analysis of newly synthesized potent local anesthetic with chiral molecular structure. Absolute structure and absolute configuration on four chiral centres was determined using microcrystalline single-diffraction with anomalous scattering of X-ray radiation azimuthal scan technique. Phase analysis for new compound (KP23SS= and its epimer )KP23RS= was carried out using classical and sznchrotron radiation powder diffraction. Enantiopuritz of the bulk material was verified for both isomers bz comparison of experimental and simulated high+resolution powder difraction diagrams. The presence of two new polzmorphic phases of KP23RS was documented. Comparative conformational analzsis was carried out using differential Fourier sznthesis and least+squares molecule overlao technique. A model of epimeric disorder was discussed for the homochiral phase.
Authors and Affiliations
Jacek Grochowski, Pawel Serda, Marta Pasenkiewicz-Gierula, Ryszard Czarnecki, Tadeusz Librowski, Stanislaw Lochynski, Bozena Frackowiak
Keywords
Related Articles
- EP ID EP112861
- DOI -
- Views 143
- Downloads 0
Structural characterization of Carane Derivative Stereoisomers
The paper reports on structural investigation and phase analysis of newly synthesized potent local anesthetic with chiral molecular structure. Absolute structure and absolute configuration on four chiral centres was dete...