Structural studies on ligand binding ability of Siglec-2 using molecular modeling techniques
Journal Title: International Journal of Experimental Research and Review - Year 2018, Vol 15, Issue 1
Abstract
Siglecs are attractive therapeutic target of the major homologous subfamily of I-type lectins. The primary role of Siglecs may actually lie in the recognition and phagocytosis of bacterial pathogens that express sialic acids, maintenance of myelin organization, and inhibition of neurite outgrowth, cell-cell interactions between neurons and glial cells etc. Siglec-2, a member of the Siglec family expressed on the surface of maturing B cells and B cell lymphomas and regulates signal transduction. In this work, 3-D structure of human Siglec-2 was predicted using molecular modeling techniques. The structure of the complex in solution of Siglec-2 with ligand, 6′-Sialyl-N-acetyl lactose (6′-SialylLacNAc) was predicted using a novel docking technique. The structural analysis of the complex and calculation of theoretical dissociation constant value will help to ascertain functional roles of such sugar binding protein.
Authors and Affiliations
Madhumita Dandopath Patra
Keywords
Related Articles
- EP ID EP702198
- DOI https://doi.org/10.52756/ijerr.2018.v15.008
- Views 100
- Downloads 0
Densitometric HPTLC analysis of the Acacia catechu wild fractions for phenolics
Traditional "Ayurvedic" medicine from India has traditionally used Acacia catechu. The herbal extract is the primary component, although there have been no attempts to standardize it as an active agent or marker. A chrom...
Development and validation of RP-HPLC method for simultaneous estimation of Ertugliflozin and Sitagliptin in bulk drug and tablet dosage form
To treat type 2 diabetes, in a combined tablet dosage form the ertugliflozin and sitagliptin were administered. Considering the less complication and readily availability of HPLC, the main objective of present study was...
Apoptosis: From Oncogenesis to Oncotherapy
Cell death is critical in maintaining the balance between cell proliferation and elimination in all living organisms. Among the different modalities of regulated cell death, apoptosis remains the most extensively studied...
Assessment of the SPF and Anti-Irritating Properties of Sunscreen designed for Retinol users
Vitamin A and its derivatives, also known as retinoids, when applied topically for anti-ageing benefits, typically cause erythema and dryness on the skin, which are considered significant and common side effects. Further...
Optimizing User Satisfaction in Movie Recommendations Using Variable Learning Rates and Dynamic Neighborhood Functions in SOMs
Customized movie recommendations are crucial in elevating user satisfaction and engagement in the era of vast online entertainment options. This study presents an innovative approach utilizing Enhanced Self-Organizing Ma...