Structure of Single Particles from Randomly Oriented Ensembles Using an X-Ray Free Electron Laser
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2017, Vol 1, Issue 7
Abstract
The method of time-resolved crystallography offers a method of studying fast changes in structure during a chemical reaction. However, being a crystallographic method it is restricted to crystal structures. The problem with this is that most chemical reactions under physiological conditions happen in solution and not on molecules which are part of a crystal. The main problem with trying to find chemical reactions in solution is that one needs a powerful source of X-rays which will give a measurable signal even from small numbers of randomly oriented molecules. The newly developed X-ray free electron laser allows this when combined with a novel theoretical technique. Of course we understand one of the strengths of working with crystals is that the signal comes not from one but from trillions of identically oriented unit cells. The fact that the unit cells are identically oriented means that the X-rays do not have to scatter off a single molecule (or unit cell) to give a sensible signal. Since all molecules are identically oriented information about an idealized average molecule may be obtained from scattering by a crystal even though the different photons scatter off different molecules. The problem is that most chemical reactions do not take place in crystals.
Authors and Affiliations
SS Kim, DK Saldin, S Wibowo
Keywords
Related Articles
- EP ID EP572667
- DOI 10.26717/BJSTR.MS.ID.000574
- Views 181
- Downloads 0
Does Early Egg Consumption Reduce Egg Allergy? Evidence from Randomised Controlled Trials
We refer to the six randomised controlled trials (RCTs) (PETIT; Natsume et al, HEAP; Bellach et al, BEAT; Tan et al and STEP; Palmer et al, EAT; Perkin et al, STAR; Palmer et al, published within the last five years. The...
Determinants of Satisfaction with Training Process among Final Year Nursing Students at Kenya Medical Training College
Purpose: To identify the factors that influenced satisfaction with the training process among the final year nursing students in Kenya Medical Training College. Method: This was a descriptive correlational study where bo...
Adverse Health Consequences of Dietary Advanced Glycation End Products (ages) and Inhibitory Effects of Natural Ingredients on Ages
Dietary advanced glycation end products (AGEs) may result in various adverse health consequences, such as inflammation, cancer, liver diseases, obesity, cardiovascular diseases, diabetes, proteostatis impairment and memo...
Rethinking the Treatment of Pathologic Scars
Over 100 million people develop a pathologic scar every year worldwide [1] Attempts to treat scars in the United States alone account for almost $15 Billion of expenditures with a large percentage of patients left with s...
Modeling of an Intelligent Electronic Medical Records System
This paper proposes a model for intelligent EMRs, which includes integrated user interfaces and multiplayer data models. The new model of EMRs should provide more interoperability and Artificial Intelligence (AIs) featur...