STUDIES ON ADSORPTION CHLORAMFENICOL ON CHITOSANS IN PHARMACEUTICAL “IN VITRO” MODEL
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2013, Vol 0, Issue
Abstract
In clinical practice in the treatment of obesity, uses several natural macromolecular compounds, whose functioning is based on supporting the weight loss. In use of dietary supplements containing chitosan, sometimes reaches the illness and in the treatment, which the other therapeutic agents are chemotherapeutic drugs. The aim of our study was to determine the binding capacity of chloramphenicol chemotherapeutic depending on variable factors physico-chemical properties, present in the intestinal tract model of chitosans present in the drugs. The phenomenon of adsorption of chloramphenicol was examined by a dynamic model simulating the conditions of the pharmaceutical in vitro, the amount of adsorbed chemotherapy. The obtained results show that chloramphenicol is adsorbed by chitosans at pH ranges used, and the binding capacity depends on the pH of the environment and the viscosity and concentration of the chemotherapeutic agent as well as the type of chitosan and the additional substances present in the gastrointestinal tract. The average size of the adsorption system chemotherapeutic chitosan-nutrients depending on the pH of the medium ranged from 22.3 to 100.0%. Maximum number of adsorption points above pH 7 (chitosan precipitated polymer forming the emulsion-gel system)
Authors and Affiliations
Jan Meler, Bożena Grimling, Paweł Biernat, Janusz Pluta
Keywords
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- EP ID EP73513
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