Study of A1298C variation in MTHFR gene as a molecular risk factor for male infertility in Iran
Journal Title: Central Asian Journal of Medical and Pharmaceutical Sciences Innovation - Year 2021, Vol 1, Issue 1
Abstract
Methylenetetrahydrofolate reductase is an important enzyme in folate metabolism pathway. There are some studSome studies investigateding the correlation of a common gene variation (A1298C) with male infertility in a specific Caucasian population (Iran), but the outcomes are controversial. SoThus, the current study employed a meta-analysis to determine the association of mentioned variation with male infertility in the above-mentionedIranian population. PubMed, Google Scholar, EMBASE, SID, and Magiran databases were searched to recognize eligible publications. The odds ratios (ORs) was used with corresponding 95% confidence intervals (95% CIs) to assess the strength of genetic association analysis. The data were analyzed through Metagenyo software. In overallGenerally, three qualified papers were found and included in the quantitative synthesis (meta-analysis). The obtained data displayed that the variation is not correlated with male infertility in co-dominant genetic models. Also, the results showed no significant heterogeneities among eligible included studies. Moreover, publication bias did was not observe detected in the current analysis. This meta- analysis proposes that A1298C polymorphism in MTHFR gene is not correlated with male infertility in Iranian population, and it could not be counted considered as a risk factor for male infertility.
Authors and Affiliations
Omid Hassanpour
Keywords
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- EP ID EP714120
- DOI 10.22034/CAJMPSI.2021.01.03
- Views 87
- Downloads 0
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