STUDY OF ANTIOXIDANT STATUS IN TYPE-II DIABETIC RETINOPATHY CASES
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 27
Abstract
Diabetic Retinopathy is a progressive disorder. It is the most common cause of blindness in people aged 30-60 years. The retina has high content of polyunsaturated fatty acid and glucose oxidation relative to any other tissue. Hyperglycemia and dyslipidemia in diabetes mellitus induce increased lipid peroxidation and reactive oxygen species formation, an important mechanism in the pathogenesis of micro-angiopathy. The oxidative stress is an imbalance between excess oxidative species formation and impaired removal of the reactive oxygen species by antioxidant defence system like vitamin A, vitamin C, vitamin E, superoxide dismutase, glutathione peroxidise and catalase. Hence the study over a period of one and a half month from 1 st May to June 15th 2015 with 20 diabetic retinopathy cases and 20 control cases was undertaken to evaluate the oxidative status and serum vitamin antioxidants levels in diabetic retinopathy cases. Our study using descriptive statistical analysis has shown positive correlation between hyperglycemia and MDA levels and oxidative stress with simultaneously decrease in antioxidant levels and serum vitamin like A, C and E.
Authors and Affiliations
Bhaskar Balasundaram, Surendra H. R
Keywords
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- EP ID EP230996
- DOI 10.18410/jebmh/2015/571
- Views 106
- Downloads 0
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