Study of association of MTHFR 677 C→T gene polymorphism in coronary artery disease
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2018, Vol 27, Issue 2
Abstract
Coronary Artery Disease (CAD) continues to be a major cause of mortality, globally for the last few decades. Hyperhomocysteinemia (HCA) resulting from MTHFR 677 C→T polymorphism as a reason for CAD in India has been debatable. The purpose of this study was to analyze the possible association between MTHFR 677C→T polymorphism with CAD by performing a case control study in subjects from Navi Mumbai. Subjects with CAD (n=49) below the age of 65 were compared with a similar number of age and gender matched controls without CAD. According to genotypic analysis, 46 and 48 individuals with CC genotype; 3 and 1 individual with CT genotype were found in cases and controls respectively. No individuals with TT genotype were found in either group. Statistical analysis of biochemical parameters revealed significantly higher levels of plasma homocysteine (Homocysteine) in cases than in controls (p= 0.00), which was statistically significant. However the analysis did not show a significant difference in the Homocysteine levels of CC and CT genotypes within the cases (or in controls). The T allele presents a higher relative risk (OR= 3.0632) in susceptibility to CAD, however, this is not statistically significant (p = 0.3361). Although our study failed to find any association between the existing polymorphisms of MTHFR gene and CAD, it did find an association between HCA and CAD.
Authors and Affiliations
Prithviraj Manohar Vijaya Shetty, Zareeful Huda Qadri, Arpith Murarka, Honey Mittal, David Mary, James Thomas
Keywords
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