Study of Clinico-Histopathological Spectrum of Leprosy who Attend to a Teaching Institute of Coastal Andhra Pradesh
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 2
Abstract
Introduction: Leprosy caused by Mycobacterium Leprae is an important public health problem. It is a chronic granulomatous disease involving skin and peripheral nerves. Histopathological examination of skin provides confirmatory diagnosis in suspected cases and gives indication of progression and regression of disease under treatment. The aim of this study is to identify the clinical pattern of leprosy and its clinicohistopathological correlation. Methods: Clinico Pathological study of 35 leprosy patients was undertaken in the Department of Pathology. Biopsies were taken from most active skin lesions by Department of Dermatology and fixed in 10% formalin. The tissue section stained with Hematoxylin and Eosin and Fite Faraco staining for identifying the bacilli. Histopathological findings were graded according to Ridley and Jopling scale. ClinicoHistopathological correlation was done. Results: Maximum numbers of patients were in their 3rd Decade (28.57%).Males were contributing to majority of the patients (72.5%). One case that we received of LL type was a male. In the clinical spectrum of 35 cases, IL was not contributing to any clinical diagnosis, TT was in 1 (2.85%) case, BT in 19 (54.28%) cases, BB in 5 (14.28%) cases, BL in 5(14.28%) cases, and LL in 5 (14.28%) cases. Common type of skin lesion observed was Macule (54.28%). Commonest site of lesion was Trunk and Upper Limbs (22.85%). Most of the cases were presented as Hypopigmented Lesions (65.71%). Most of the patients showed Anesthetic Lesion (48.57%). In the histopathological spectrum IL cases were contributing to 48.57% of cases, TT cases were 2.85%, BT cases were 25.71%, BB cases were 2.85%, BL cases were 17.14%, LL cases were 2.85%. Overall concordance between Clinical and Histopathological diagnoses was 20%. Conclusions: Clinical examination or histopathological examination alone may not stand as ideal diagnostic tools in diagnosing and classifying leprosy. There are factors like interobserver variation, overlap between different types of leprosy. Clinico histopathological disparity may be reduced by following the criteria strictly both clinically and histopathologically there by providing the patient early and adequate treatment to prevent morbid disabilities.
Authors and Affiliations
Vallamreddy Siva Kota Reddy
Keywords
Related Articles
- EP ID EP514040
- DOI 10.21088/ijprp.2278.148X.7218.17
- Views 91
- Downloads 0
Patterns of Donor Deferral among Blood Donors: Study at a Tertiary Care Hospital
Background: Blood transfusion is a critical and lifesaving procedure as even a unit of blood can save a patient in need [1]. Safe and adequate supply of blood and blood products is a major public health issue faced globa...
Editorial
Not available
Diagnostic Utility of Body Fluid Cytology
Background: Cytological examination of various body fluids like ascitic, pleural, synovial, CSF, urine etc, plays an important role in diagnosing various non- neoplastic and neoplastic conditions. Hence, this study is co...
Histopathological Evaluation of Non-Neoplastic and Neoplastic Lesions of Cervix
Background: Cervix is one of the most common target organs for both non neoplastic and neoplastic diseases of the female genital tract. Cervical cancer is the second most common cancer worldwide having poor prognosis. Ca...
A Histopathologic Study of Papulosquamous Lesions of Skin
Papulosquamous group of skin lesions have certain common clinical presentations and lead to confusion in diagnosis. We undertook this study to analyze the histomorphological findings of various papulosquamous lesions of...