Study of coagulation profile in IHD patients
Journal Title: Medpulse International Journal of Physiology - Year 2018, Vol 7, Issue 1
Abstract
Background: Epicardial coronary arteries are the major site of atherosclerotic disease. A thrombus composed of platelet aggregates and fibrin strands traps red blood cells and can reduce coronary blood flow, leading to the clinical manifestations of ischaemic heart disease (IHD). A positive association of coagulation factors has been implicated with risk of IHD. This study was under taken to assess the association of coagulation factors in IHD patients by comparing them to normal subjects. Methods: This case control study includes fifty IHD male patients aged 30-50 years as cases and fifty apparently healthy age and sex matched male subjects as controls. Venous blood samples were collected from the subjects which were analyzed for coagulation parameters such as prothrombin time (PT), activated partial thromboplastin time (aPTT) and fibrinogen levels. Result: The PT and aPTT in cases were significantly lower and fibrinogen levels were higher in cases than in controls. Conclusion: Shortened levels of PT and aPTT are seen in IHD patients than compared to normal subjects and hence these tests prove as reliable diagnostic tools for IHD. Higher fibrinogen levels, by means of increasing viscosity, also seems to be n independent risk factor for IHD.
Authors and Affiliations
Aiesha Durrebar Younus Khan, Ashwini D Pujari
Keywords
Related Articles
- EP ID EP410146
- DOI -
- Views 179
- Downloads 0
Association of cigarette smoking with hearing loss: Cross sectional study among sample population of Kolar
Background: The link between cigarette smoking as a risk factor for hearing loss was established over 40 years ago. This study was an attempt to observe the association between smoking and changes in hearing thresholds i...
Effect of pranayama training on audio-visual reaction time
Present study was conducted to observe effect of short duration pranayama on audio-visual reaction time. One sixty healthy 1st year M.B.B.S. students were participated in the study. Readings of height (meter), weight (kg...
Influence of glycaemic control on platelet count in type II diabetics in absence of vascular complications
Background: Diabetes mellitus (DM) has attained a state of a global emergency with increasing prevalence worldwide. Altered thrombocyte morphology, count and function have been reported with diabetics. The present study...
Impact of E-learning as a supplementary teaching learning tool in physiology
Background: The present teaching- learning activity caters to the requirements of average learners. E-learning has the potential to promote learning at learner’s convenience and pace. In the present study, learning outco...
A study of cardiovascular parameters in males and females at rest
Background: Heart Rate Variability (HRV) is considered a good indicator of autonomic control related to cardiovascular health, and has been studied in a range of situations in order to determine the variables that influe...